1982.9-1986.7 武汉大学 微生物专业 本科

1986.9-1989.7 中国科学院水生生物研究所 水生生物学专业 硕士

1994.8-1999.5 新加坡国立大学 动物学专业 博士

1989.7-1994.6 中国科学院水生生物研究所  助理研究员

1999.5-2003.4 Case Western Reserve University（USA）  博士后

2003.5-2005.4 University of Pennsylvania (USA)  博士后

2005.5至今 中国科学院水生生物研究所  研究员

水产养殖（硕士生，博士生）

自2005年回国组建学科组以来，主要通过转基因、基因编辑等技术，围绕鲤科鱼类生长代谢和繁育的内分泌调控、优良等位变异的分子标记辅助育种等方面开展研究，通过基因编辑技术，率先构建了3种单基因敲除的鱼类生长模型，发现促进鱼类生长的2种内分泌调控方式：1）提升脂肪利用能力，为个体生长期提供能量，可促进鱼类生长；2）钝化鱼类应激反应，降低基础运动和代谢率，可促进鱼类生长。近期也通过基因编辑技术实现了黄河鲤的雄、雌单性性别稳定遗传群体的构建，获得的全雌黄河鲤群体养殖可较普通性别混养群体提升产量约30%。已在Nat. Med.、PNAS、Cell Reports、eLife、Sci Bull.、Redox Biol.、Engineering、Sci China•Life Sci.、J Mol. Cell. Biol.、Human Mol. Genetics、Mol. Cell. Biol.、Endocrinology、Biol.Reprod.、J. Biol. Chem.等重要国际学术刊物发表第一或通讯作者文章50余篇，其引用超过1400余次。

2010年获得国家自然科学基金委杰出青年基金资助，2014年领衔“鱼类生物学及渔业生物技术研究创新团队”入选科技部重点领域创新团队，2016年入选中组部“万人计划科技创新领军人才”。曾主持多个国家973项目课题、国家自然科学基金委重点项目等，现主持有“蓝色粮仓”科技专项 “水产养殖生物性别和发育的分子基础与调控机制”项目等科研项目。

代表性论文：

1. Zhai G, Shu T, Yu G, Tang H, Shi C, Jia J, Lou Q, Dai X, Jin X, He J, Xiao W, Liu X, Yin Z*. 2022. Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLife, 11:e66118.

2. Huang J, Shi C, Gao Y, Su J, Shu Y, Zeng N, Zhai G, Jin X, Han D, He J, Lou Q*, Yin Z*. 2021. Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio). Aquaculture. 545:737207. DOI: 10.1016/j.aquaculture.2021.737207.

3. Shi, XT., Ye, C., Qin, XF., Zhou, LL., Xia, CH., Cai, TY., Xie, YY., Yin, Z.*, Hu, GF.* 2021. Novel pituitary actions of TAC4 gene products in teleost. International Journal of Molecular Science. In press

4. Xia, CH., Qin, XF., Zhou, LL., Shi, XT., Cai, XT., Xie, YY., Li, W., Du, RX., Ouyang，Y., Yin, Z.*, Hu, GF.* 2021. Reproductive regulation of PrRPs in teleost: the link between feeding and reproduction. Frontier in Endocrinology. In press.

5. Song, J., Lu, Y., Cheng, XX., Shi, C., Lou, QY., Jin, X., He, JY., Zhai, G*., Yin, Z.* 2021. Functions of the Thyroid-Stimulating Hormone on key developmental features revealed in a series of zebrafish dyshormonogenesis models. Cells. 10(8); DOI10.3390/cells10081984.

6. Xu, S., Zhou, L., Chen, X., Hu, Q., Shi, X., Xia, C., Zhang, H., Jia, J., Yin, Z.*, Hu, GF.* 2021. Novel pituitary actions of NKB for anorectic peptides regulation in grass carp. Aquaculture. 531: https://doi.org/10.1016/j.aquaculture.2020.735857.

7. Shi, C., Lou, Q., Fu, B., Jin, J., Huang, J., Lu, Y., Zhai, G., Xie, S., Tong, J., Gui, G., Yin, Z.* 2021. Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in Gibel carp (Carassius gibelio). SCIENCE CHINA Life Sciences. published online on Apr 30, 2021.

8. Zhai, G., Shu, T., Chen, K., Lou, Q., Jia, Y., Huang, J., Shi, C., Jin, X., He, J., Jiang, D., Qian, X., Hu, W., Yin, Z.* 2021. Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carp. Engineering. 8,181-189.

9. Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z*., Yin, Z.* 2021. Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of Reproduction. Published ahead print.

10. Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Wan, X., Guan, W., Su, K., Ye, M., Gao, X.*, Yin, Z.*, Li, X.*. 2021. Ghrelin Modulate Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brian, Behavior, and Immunity. Available online 4 Jan.2021.

11. Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z.* 2020. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of Molecular Cell Biology. 12(4): 291-304.

12. Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z.*, Zheng, F.* 2020. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. Vol: 28 UNSP 101355

13. Shang G., Peng, X., Ji, C., Zhai, G., Ruan, Y., Lou, Q., Jin, X., He, J., Wang, H., Yin Z.* 2019. Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of Reproduction. 101(4):760-770.

14. Shu, T., Shu, Y., Gao, Y., Jin, X., He, J., Zhai, G., Yin, Z.* 2018. Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Frontiers in Endocrinology. Vol. 9: fendo. 2018.00683

15. Zhai, G., Shu, T., Xia, Y., Lu, Y., Shang, G., Jin, X., He, J., Nie, P., Yin, Z.* 2018. Characterization of the sexual traits development in the cyp17a1-deficient zebrafish. Endocrinology. 159(10): 3549-3562.（杂志年度top10%高被引文章）

16. Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z.* 2017. LRH-1 sense signaling form phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics. 44(6): 307-318. （封面文章）

17. Dai X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z.* 2017. Tdrd12 is essential for germ cell development and maintenance in zebrafish. International Journal of Molecular Sciences. 18: (6):1127. 

18. Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* 2017. Fatty acid oxidation in zebrafish adipose tissue is promoted by 1α,25(OH)2D3. Cell Reports. 19(7): 1444-1455. （国际维生素D学会年会点评的2017-2018年间最具影响的12篇文章）

19. Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin, Z.* 2017. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Chinese Sciences Bulletin. 62(3):197-203.

20. Gao, Y., Dai, Z., Shi, C., Zhai, G., Jin, X., He, J., Lou, Q.*, Yin, Z.* 2016. Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in Endocrinology. 7: 10.3389/ fendo.2016.00088

21. Dai, X., Zhang, W., Zhuo, Z., He, J., Yin, Z.* 2015. Neuroendocrine regulation of somatic growth in fishes (review). Science China. Life Sciences. 58: 137-147.

22. He, W., Dai, X., Chen, X., He, J., Yin, Z.* 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.

23. Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)：2199-2212.

24. Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E*., Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer’s vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.

25. Mei, Y., Yin, N., Jin, X., He, J., Yin, Z.* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154 (12):4640-4649.

26. Chen, D., Li, L., Tu, X., Yin, Z.*, Wang, Q.* 2012. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22 (5)：963-976.

27. Jiang, N., Jin, X., He, J., Yin, Z.* 2012. The roles of follistatin1 in regulation of zebrafish fecundity and sexual differentiation. Biology of Reproduction. 87(3)：54.1-8.

28. Ji, C., Jin, X., He, J., Yin, Z.* 2012. Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2)：149-155.

29. Lou, Q., He, J., Hu, L., Yin, Z.* 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823(5): 1024-1032. (通讯作者).

30. Sun, L., Xu, W., He, J., Yin, Z.* 2010. In vivo alternative assessment of the chemicals that interferre with anterior pituitary POMC expression and interregnal steroidogenesis in POMC:EGFP transgenic zebrafish. Toxicology and Applied Pharmacology. 248(3): 217-225.（

31. Li, X., He, JY., Hu, W., Yin, Z.* 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6): 2767-2774.

32. Ma, L., Li, D., Wang, J., He, J., Yin, Z.* 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.

33. Trivedi, CM.*, Luo, Y*., Yin, Z.*, Zhang, M., Zhu, W., Wang, T., Floss, T., Goettlicher, M., Noppinger, PR., Wurst, W., Ferrari, VA., Abrams, CS., Gruber, PJ., Epstein, JA. (2007). HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3ß. Nature Medicine. 13(3): 324-331. (*等同第一作者).

34. . Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. (2006). Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am. J. Physiol. Lung Cell Mol. Physiol. 291：L191-199. (*等同第一作者)

35. Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. (2003). C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. J. Biol. Chem. 278, 22838-22845.

36. Yin, Z., Haynie, J., Yang, X., Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. (2002) The essential role of Cited2, a negative regulator for HIF-1 in heart development and neurulation. Proc. Nat. Acad. Sci. USA. 99, 10488-10493.

出版专著：

1. 殷战，廖传松，刘家寿等，2021年，《丹江口水库增养殖容量与放养调控技术》，科学出版社。

2. 桂建芳，周莉，殷战，胡炜，童金苟，孙永华，肖武汉，2021年，《水产遗传育种学》，科学出版社

授权专利：

1. 殷战;梅芸;尹乃达;贺江燕。肾上腺素受体激动剂诱导胚胎型珠蛋白表达及其用途。专利号CN101926998B，授权公告日：2013年9月3日。

2. 殷战;石闯;童金苟;解绶启;娄气永;翟刚。一种促进鱼类生长性状改良的方法。专利号：CN201910413299.6，授权公告日：2019年5月17日。

中国动物学会斑马鱼分会、中国动物学会比较内分泌学会理事

Engineering、Frontiers in Endocrinology、PLoS ONE等期刊编委

已指导毕业硕士、博士毕业生近20名，多名学生获中科院院长奖学金优秀奖等各类院级、武汉分院级奖学金。

现指导在读硕士、博士在读研究生8名。

欢迎有生物学背景的考生报考。