1987.9-1991.6 湖北大学 生物系 生物专业 本科

1993.9-1996.6 中国科学院水生生物研究所 遗传学专业 硕士

2000.9-2003.6 中国科学院水生生物研究所 遗传学专业 博士

水产养殖（硕士生，博士生）

鱼类抗病毒感染免疫学

本实验室主要聚焦鱼类响应病毒感染的天然免疫分子机理及应用。致力于挖掘鱼类响应病毒感染的相关基因，解析相关基因的功能、调控机制及信号通路，发现特异于鱼类物种的抗病毒感染免疫规律，尤其是鱼类干扰素介导的天然抗病毒免疫反应的分子机理，鉴定潜在应用于鱼类抗病育种实践的关键分子。近期拟在三个方面开展研究工作：抗病毒感染的分子机制及分子调控；抗病毒因子的功能及应用；脊椎动物免疫系统发育及分子进化。近5年来在Journal of Immunology、Frontiers in Immunology、PLoS Pathogens等刊物发表论文十多篇。

1.      2018.12-2022.12科技部重点研发计划项目课题（淡水鱼类抗病与抗逆性状形成的分子机理），760万元，主持

2.      2020.1-2023.12．国家自然科学基金面上项目（银鲫a亚类干扰素基因IFNa1转录成胞外和胞内干扰素两个转录本的选择性剪接机理及抗病毒机制），58万，主持

3.      2018.1-2021.12．国家自然科学基金面上项目（鱼类TRIM16家族基因TRIM16a负调控干扰素抗病毒免疫反应的功能研究），65万，主持

4.      2019.8-2024.8中国科学院战略先导科技专项A类子任务（鲤病毒感染响应的分子网络1），108万，主持

5.      2020.8-2022.12武汉市科技计划项目应用基础前沿专项（新型负调控因子TRIM16L 应用于鱼类抗病育种的机制研究），50万，主持

本学科组聚焦鱼类干扰素介导的天然抗病毒免疫这个研究主题。在揭示鱼类存在与哺乳类相对保守的天然免疫反应机制的基础上，发现了一系列特异于鱼类的干扰素抗病毒免疫新机制：鉴定了一批鱼类特异的参与干扰素抗病毒免疫反应的基因如PKZ、IRF11、以及Gig1和Gig2新基因家族等，并揭示出由这些特异基因介导的天然抗病毒反应途径和分子机理；发现鱼类特有基因家族finTRIM家族在不同鱼类物种中独立扩增的进化规律，对鲫特异的FTRCA1的功能研究，揭示出鱼类物种特异的干扰素抗病毒免疫反应新机制；发现鱼类病毒核酸识别受体LGP2在病毒感染早期发挥正调控而在病毒感染晚期转向负调控、有别于哺乳类的分子机制；发现鱼类干扰素通过调控自身表达放大干扰素反应的独特机理；发现鱼类和哺乳类独立形成相似的干扰素反应调控机制网络的趋同进化规律；发现脊椎动物的干扰素反应经历了一个由转录因子IRF3介导的、从粗放调控到精确调控的演化规律。

近年发表部分论文：

1.      Feng H, Zhang YB, Gui JF, Lemon SM, Yamane D. Interferon regulatory factor 1 (IRF1) and antipathogen innate immune responses. PLoS Pathog 2021, 17(1): e1009220

2.      Zhao X, Gong XY, Li YL, Dan C, Gui JF, Zhang YB^*. Characterization of DNA binding and nuclear retention identifies zebrafish-specific IRF11 as a positive regulator of IFN antiviral response. Journal of Immunology. 2020, 205 (1):237-250

3.      Wu CX, Zhang YB^* and Hu CY^*. PKZ, a Fish-Unique eIF2 Kinase Involved in Innate Immune Response. Front. Immunol. 2020,11:585.

4.      Xiong Y, Dan C, Ren F, Su Z, Zhang YB^*, Mei J^*. Proteomic profiling of yellow catfish (Pelteobagrus fulvidraco) skin mucus identifies differentially-expressed proteins in response to Edwardsiella ictaluri infection. Fish Shellfish Immunol. 2020;100:98-108.

5.      Zang ZX, Dan C, Zhou L, Zhang QY, Gui JF, Zhang YB^*. Function characterization and expression regulation of two different-sized 3’untranslated region-containing interferon genes from clone F of gibel carp Carassius auratus gibelio. Molecular Immunology, 2020,119:18–26.

6.      Li YL, Zhao X, Gong XY, Dan C, Gui JF, Zhang YB^*. Molecular identification and function characterization of four finTRIM genes from the immortal fish cell line, EPC. Developmental and Comparative Immunology, 2020, 113:103775.

7.      李依琳，张义兵^*。鱼类RLR介导的抗病毒免疫反应的泛素化修饰调控。水生生物学报。2020，44(5): 976 -988 doi: 10.7541/2020.113

8.      Song W, Zhang YB, Zhang XJ, Gui, JF. De Novo Transcriptome Assembly of Four Organs of Collichthys Lucidus and Identification of Genes Involved in Sex Determination and Reproduction. PLoS One. 2020 Mar 27;15(3):e0230580.

9.      Wu M, Dan C, Gui JF, Zhang YB^*. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription. Fish & Shellfish Immunology, 2019;90:180-187.

10.   Wu M, Zhao X, Gong XY, Wang Y, Gui JF, Zhang YB^*. FTRCA1, a species-specific member of finTRIM family, negatively regulates fish interferon response through autophage-lysosomal degradation of TBK1. Journal of Immunology, 2019,  202  (8):  2407-2420

11.   Gong XY, Zhang QM, Gui JF, Zhang YB^*. SVCV infection triggers fish IFN response through RLR signaling pathway. Fish & Shellfish Immunology, 2019, 86:1058-1063

12.   Zhang QM, Zhao X, Li Z, Wu M, Gui JF, Zhang YB^*. Alternative splicing transcripts of zebrafish LGP2 gene differentially contributes to interferon antiviral response. Journal of Immunology, 2018,  200  (2):  688-703

13.   Gao FX, Lu WJ, Wang Y, Zhang QY, Zhang YB, Mou CY, Li Z, Zhang XJ, Liu CW, Zhou L, Gui JF. Differential expression and functional diversification of diverse immunoglobulin domain-containing protein (DICP) family in three gynogenetic clones of gibel carp. Dev Comp Immunol. 2018;84:396-407.

14.   Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep. 2017;21(1):195-207.

15.   熊亚玮，张义兵^*，桂建芳。斑马鱼IRF11基因的鉴定、亚细胞定位及表达特征。水生生物学报，2017 , 41 (1) :1-8。

16.   Feng H, Zhang QM, Zhang YB^*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3, and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes. Journal of Immunology, 2016, 197(5):1893-904.

17.   Chen C, Zhang YB^*, Gui JF. Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes. Dev Comp Immunol, 2015, 52:112–122。

18.   Feng H, Zhang YB^*, Zhang QM, Li Z, Zhang QY, Gui JF^*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNj1 and IFNj3 promoters downstream of MyD88 signaling. Journal of Immunology, 2015, 194: 1225–1238.

19.   Sun F, Zhang YB^*, Jiang J, Wang B, Chen C, Zhang J, Gui JF^*. Gig1, a novel antiviral effector involved in fish interferon response. Virology, 2014,448:322–332

20.   Li S, Lu LF, Feng H, Wu N, Chen DD, Zhang YB, Gui JF, Nie P, Zhang YA. IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. J Immunol, 2014, 193(3):1100-9.

21.   Liu TK, Zhang YB^*, Liu Y, Sun F, Gui JF^*. Cooperative roles of fish protein kinase containing Z-DNA binding domains and double-stranded RNA-dependent protein kinase in interferon-mediated antiviral response. Journal of Virology. 2011, 85(23):12769-80.

22.   Zhang YB^*, Gui JF^*. Molecular regulation of interferon antiviral response in fish. Developmental and Comparative Immunology. 2012,38:193-202

23.   Sun F, Zhang YB^*, Liu TK, Shi J, Wang B, Gui JF^*. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. Journal of Immunology. 2011, 187(5):2531-9.

24.   Sun F, Zhang YB^*, Liu TK, Gan L, Yu FF, Liu Y, Gui JF^*.Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. Journal of Immunology. 2010,185:7573-7582.

25.   Yu FF, Zhang YB^*, Liu TK, Liu Y, Sun F, Jiang J, Gui JF^*.Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Molecular Immunology. 2010, 47(14):2330-2341.

26.   Zhu R, Zhang YB, Zhang QY, Gui JF. Functional domains and the antiviral effect of the dsRNA-dependent protein kinase PKR from Paralichthys olivaceus. Journal of Virology, 2008, 82(14):6889-901.

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