职 称: | 研究员 |
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学 历: | 博士研究生 |
联系方式: | 86-27-68780087 |
电子邮件: | w-xiao@ihb.ac.cn |
办 公 室: | 2号实验楼510 |
个人网页: | http://www.ihb.cas.cn/yjdw/yjy/index_83634.html?json=http://sourcedb.ihb.cas.cn/cn/gb/yjy1/ssswfzyxbswxyjzx_172773/200907/t20090722_5749614.json |
1985.9-1989.6 武汉大学 细胞生物学专业 本科 1989.9-1992.6 中国科学院水生生物研究所 水生生物学专业 硕士 1994.9-1997.8 中国科学院水生生物研究所 水生生物学专业 博士 |
1992.7-1994.9 中国科学院水生生物研究所 研究实习员 1994.10-1998.10 中国科学院水生生物研究所 助理研究员 1998.11-2003.10 美国西北大学 博士后/研究助理 2003.10-2005.12 美国西北大学 研究助理教授 2005.12至今 中国科学院水生生物研究所研究员 |
遗传学(硕士生,博士生) |
1. 鱼类耐低氧的分子机制与耐低氧新品种培育的遗传基础 2. 鱼类抗病毒感染的分子机制与抗病新品种培育的遗传基础 3. 鱼类低氧胁迫反应与抗病毒先天免疫反应交互作用的分子机制 |
1. 2019.1-2023.12 国家自然科学基金重点项目:鲫耐低氧优良性状的遗传基础,284万元,主持 2. 2018.10-2022.11 国家重点研发计划“蓝色粮仓”项目:重要养殖生物生物应对低氧胁迫的生理和发育响应机制与生态效应研究,289万,主持 3. 2018.1-2023.12 国家自然科学基金创新群体项目:鱼类分子设计育种,200万,参加 4. 2019.10-2023.12 中国科学院先导专项A:鲤逆境胁迫响应的分子网络,600万,主持 |
本实验室聚焦于鱼类耐低氧和抗病的遗传基础,开展了系统的研究工作,取得了一些原创性的结果,发表了一系列研究论文。 代表性论文:(通讯作者用*标明) 1. Junji Zhu, Xiong Li, Xiaolian Cai, Huangyuan Zha, Ziwen Zhou, Xueyi Sun, Fangjing Rong, Jinghua Tang, Chunchun Zhu, Xing Liu, Sijia Fan, Jing Wang, Qian Liao, Gang Ouyang, Wuhan Xiao*. Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity. Molecular Cell, 2021, 81, 1-16. 2. Xiaolian Cai , Ziwen Zhou, Junji Zhu , Qian Liao , Dawei Zhang , Xing Liu , Jing Wang , Gang Ouyang , Wuhan Xiao* . Zebrafish hif-3α modulates erythropoiesis via regulation of gata-1 to facilitate hypoxia tolerance. Development, 2020, doi: 10.1242/dev.185116. 3. Guangqing Yu , Xing Liu , Dawei Zhang, Jing Wang, Gang Ouyang , Zhu Chen, Wuhan Xiao *. Zebrafish nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development, 2020, 147(18): dev.194886. 4. Xing Liu , Chunchun Zhu, Huangyuan Zha , Jinhua Tang , Fangjing Rong, Xiaoyun Chen , Sijia Fan , Chenxi Xu , Juan Du, Junji Zhu, Jing Wang , Gang Ouyang , Guangqing Yu , Xiaolian Cai , Zhu Chen , Wuhan Xiao *. SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO Journal, 2020, 39(11): e103285. 5. Junji Zhu, Dawei Zhang, Xing Liu, Guangqing Yu, Xiaolian Cai, Chenxi Xu, Fangjing Rong, Gang Ouyang, Jing Wang, Wuhan Xiao*. Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. Development, 2019, 146(20): dev179572. 6. Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259. 7. Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017,45(22): 12700-12714. 8. Yu Chen, Chi Zhou, Wei Ji, Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumor growth. Nature Communications, 2016, 7: 11057. 9. Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098. 10. Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011, 30: 3397-3415. |