研究经历:

1. 转基因鱼研究

快速生长转基因鱼：培育获得快速生长转“全鱼”生长激素鲤鱼品系，生长速度提高42%，饵料转化效率提高11%。

抗病转基因鱼：以草鱼出血病病毒外衣壳蛋白VP7基因为靶基因，构建小发卡RNA表达载体，获得抗草鱼出血病转基因稀有鮈鲫。

2. 鱼类基因组学和分子育种研究

构建两个草鱼基因组BAC文库（EcoRI & Hind III），覆盖14.2倍草鱼基因组；构建草鱼头肾和脾脏cDNA文库，测序获得10,000条头肾EST序列，3074个unigene；克隆1,000个草鱼SSR分子标记，和一批免疫相关基因的SNP分子标记。目前正在进行草鱼遗传连锁图谱，以及草鱼生长、饵料转化效率和抗草鱼出血病性状的QTL定位研究。

研究方向：

鱼类分子遗传学

2.Su J, Yang C, Zhu Z, Wang Y, Jang S, Liao L. Enhanced grass carp reovirus resistance of Mx-transgenic rare minnow (Gobiocypris rarus). Fish Shellfish Immunol, 2009, 26(6):828-835.

3.Huang R, Gao LY, Wang YP, Hu W, Guo QL. Structure, organization and expression of common carp (Cyprinus carpio L.) NKEF-B gene. Fish Shellfish Immunol, 2009, 26(2):220-9.

4.Huang R, Sun XF, Hu W, Wang YP, Guo QL. Strcture, organization and expression of common carp (Cyprinus carpio L.) SLP-76 gene. Fish Shellfish Immunol, 2008, 24: 530-541.

5.Su Jianguo, Zhu Zuoyan, Wang Yaping, Zou Jun, Hu Wei. Toll-like receptor 3 regulates Mx expression in rare minnow Gobiocypris rarus after viral infection. Immunogenetics, 2008, 60:195-205.

6.Su Jianguo, Zhu Zuoyan, Xiong Feng, Wang Yaping. Hybrid Cytomegalovirus-U6 Promoter-based Plasmid Vectors Improve Efficiency of RNA Interference in Zebrafish. Mar Biotechnol, 2008, 10:511-517.

7.Su Jianguo, Zhu Zuoyan, Wang Yaping, Xiong Feng, Zou Jun. The Cytomegalovirus Promoter-Driven Short Hairpin RNA Constructs Mediate Effective RNA Interference in Zebrafish In Vivo. Mar Biotechnol, 2008, 10:262-269.

8.Su J, Zhu Z, Wang Y. Molecular cloning, characterization and expression analysis of the PKZ gene in rare minnow Gobiocypris rarus. Fish Shellfish Immunol, 2008, 25(1-2):106-113.

9.Hu Wei, Li Shuangfei, Tang Bin, Wang Yaping, Lin Haoran，Liu Xiaochun, Zou Jun, Zhu Zuoyan. Antisense inhibition of two sGnRH genes expression suppresses GtH synthesis and gonad development in common carp Cyprinus carpio. Aquaculture, 2007, 271: 498-506.

10.Liu Weiyi, Yun Wang,Yao Qin, Ya-ping Wang, Zhu Zuoyan. Site-Directed Gene Integration in Transgenic Zebrafish Mediated by Cre Recombinase Using a Combination of Mutant Lox Sites. Marine Biotechnology, 2007, 9(4): 420-428.

11.Wang Yun, Hu Wei, Wang Yaping, Liu Weiyi, Zhu Zuoyan. Identification and characterization of a novel splice variant of gonadotropin a subunit in the common carp (Cyprinus carpio). Journal of Fish Biology, 2007, 71: 1082-1094.

12.Liu Jing, Wang Na, Wang Yaping, Sun Yonghua, Zhu Zuoyan. Cloning, characterization and promoter analysis of common carp hairy/Enhancer-of-split-related gene, her6. Journal of Genetics, 2006, 85(3): 171-178.

13.Wang Na, Liu Jing, Wu Gang, Su Jiangguo, Wang Yaping, Sun Yonghua, Zhu Zuoyan. Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system. J Biomed Sci, 2007, 14: 767-776.

14.Wang Na, Liu Jing, WangYaping, Sun Yonghua, Zhu Zuoyan. Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Dev Genes Evol, 2007, 217: 299-305.

15.Hu Wei, Wang Yaping, Zhu Zuoyan. Progress in the evaluation of transgenic fish for possible ecological risks and its containment strategies. Science in China Series C, 2007, 50(5): 573-579.