本课题组围绕蓝藻水华的两类衍生污染物—微囊藻毒素（简称MC）和异味化合物，进行了数年的野外调查、室内分析检测技术和方法、及生态毒理学研究，在MC对人类及水生动物的健康与毒性效应、鱼类规模化控制有毒蓝藻的生态学实践、MC的代谢产物（通过GSH途径）与异味物质检测技术等方面取得了若干具有理论和实践意义的创新性研究成果。先后在相关领域核心期刊Water Research, Ecology, Journal of Ecology, Journal of Hazardous Materials, Environmental Science & Technology, Archives of Toxicology, Toxicological Sciences, Environmental Pollution, Science of the Total Environment等上发表 SCI论文87篇。截至2021年4月，SCI他引2200余次，H指数=30，多篇论文被世界卫生组织（WHO）、欧洲食品安全局（EFSA）、美国环境总署（USEPA）和加拿大卫生部（Health Canada）等列为制定MC控制标准的技术支撑文献。

代表性论文：

1.        Chen L^#, Shi T^#, Wang YT, He J, Zhao X, Wang YK, Giesy JP, Chen F, Chen Y, Tuo X, Chen J*, Xie P. Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats. Sci. Total Environ., 2021: 145196.

2.        Chen J, Xie P, Yu DZ, Xie LJ, Chen J*. Dynamic change of sedimental microbial community during black bloom-an in situ enclosure simulation study. Microb. Ecol., 2021, 81: 304-313.

3.        Zhang WZ, Shen H*, Zhang J, Yu J, Xie P, Chen J*. Physiological differences between free-floating and periphytic filamentous algae, and specific submerged macrophytes induce proliferation of filamentous algae: A novel implication for lake restoration. Chemosphere, 2020, 239: 124702.

4.        Xia WL, Chen L, Deng XW, Liang GD, Giesy JP, Rao QY, Wen ZH, Wu Y, Chen J*, Xie P*. Spatial and interspecies differences in concentrations of eight trace elements in wild freshwater fishes at different trophic levels from middle and eastern China. Sci. Total Environ., 2019, 672: 883-892.

5.        Deng XW, Qi M, Ren R, Liu JR, Sun XX, Xie P, Chen J*. The relationships between odors and environmental factors at bloom and non-bloom area in Lake Taihu, China. Chemosphere, 2019, 218: 569-576.

6.        Zhang WZ, Wang L, Chen L, Shen H*, Chen J*. Proliferation of filamentous green algae along with submerged macrophytes planting, and the role of microbe. Ecol. Eng., 2019, 139: 105570.

7.        Chen L^#, Hu YF^#, He J, Chen J*, Giesy JP, Xie P*. Responses of the proteome and metabolome in livers of zebrafish exposed chronically to environmentally relevant concentrations of microcystin-LR. Environ. Sci. Technol., 2017, 51: 596-607.

8.        He J^#, Li G^#, Chen J^#, Lin J, Zeng C, Chen J, Deng J, Xie P*. Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study. Arch. Toxicol., 2017, 91: 465-480.

9.        Chen L, Chen J*, Zhang XZ, Xie P*. A review of reproductive toxicity of microcystins. J. Hazard. Mater., 2016, 301: 381-399.

10.    Yu DZ, Xie P, Zeng C, Xie LJ, Chen J*. In situ enclosure experiments on the occurrence, development and decline of black bloom and the dynamics of its associated taste and odor compounds. Ecol. Eng., 2016, 87: 246-53.

11.    Chen L, Li SC, Guo XC, Xie P, Chen J*. The role of GSH in microcystin-induced apoptosis in rat liver: involvement of oxidative stress and NF-kB. Environ. Toxicol., 2016, 31: 552-560.

12.    Chen J, Xie P, Lin J, He J, Zeng C, Chen J*. Effects of microcystin-LR on gut microflora in different gut regions of mice. J. Toxicol. Sci., 2015, 40: 485-494.

13.    Zhao SJ, Li GY*, Chen J*. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. J. Proteomics., 2015, 114: 197-213.

14.    Li SC, Chen J*, Xie P, Guo XC, Fan HH, Yu DZ, Zeng C, Chen L. The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats. Environ. Toxicol., 2015, 3: 1470-1480.

15.    Li W, Chen J*, Xie P, He J, Guo XC, Tuo X, Zhang W, Wu LY. Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristichthys nobilis). Aquat. Toxicol., 2014, 147: 18-25.

16.    Li W, Xie P, Chen J*, He J, Guo XC, Yu DZ, Chen L. Quantitative liquid chromatography-tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile. J. Chromatogr. B., 2014, 963: 113-118.

17.    Ma ZM, Niu Y, Xie P, Chen J*, Tao M, Deng XW. Off-flavor compounds from decaying cyanobacterial blooms of Lake Taihu. J. Environ. Sci.-China., 2013, 25: 495-501.

18.    Chen J, Xu QQ, Wang TH, Collet B, Corripio-Miyar Y, Bird S, Xie P, Nie P, Secombes CJ, Zou J. Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. Dev. Comp. Immunol., 2013, 41: 137-152.

19.    Qi M^#, Chen J^#, Sun XX, Deng XW, Niu Y, Xie P*. Development of models for predicting the predominant taste and odor compounds in Taihu Lake, China. PLoS ONE, 2012, 7: e51976.

20.    He J, Chen J*, Wu LY, Li GY, Xie P*. Metabolic response to oral MC-LR exposure in the rat by NMR-Based metabonomic study. J. Proteom. Res., 2012, 11: 5934-5946.

21.    He J, Chen J*, Xie P, Zhang D W, Li G Y, Wu L Y, Zhang W, Guo X C, Li S C. Quantitatively evaluating detoxification of the hepatotoxic microcystins through the glutathione and cysteine pathway in the cyanobacteria-eating bighead carp. Aquat. Toxicol., 2012, 116-117: 61-68.

22.    Zhang DW, Yang Q, Xie P, Deng XW, Chen J*, Dai M. The role of cysteine conjugation in the detoxification of microcystin-LR in liver of bighead carp (Aristichthys nobilis): a field and laboratory study. Ecotoxicology, 2012, 21: 244- 252.

23.    Cai Y, Li HY, Hao L, Li GY, Xie P, Chen J*. Identification of cda gene in bighead carp and its expression in response to microcystin-LR. Ecotoxicol. Environ. Saf., 2012, 79: 206–213.

24.    Deng XW, Xie P*, Qi M, Liang GD, Chen J*, Ma ZM, Jiang Y. Microwave-assisted purge-and-trap extraction device coupled with gas chromatography and mass spectrometry for the determination of five predominant odors in sediment, fish tissues, and algal cells. J. Chromatogr. A, 2012, 1219: 75-82.

25.    Wu LY, Xie P*, Chen J*, Zhang DW, Liang GD. Development and validation of a liquid chromatography–tandem mass spectrometry assay for the simultaneous quantitation of microcystin-RR and its metabolites in fish liver. J. Chromatogr. A., 2010, 1217: 1455-1462.

26.    Chen J, Xie P*, Ma ZM, Niu Y, Tao M, Deng XW, Wang Q. A systematic study on spatial and seasonal patterns of eight taste and odor compounds with relation to various biotic and abiotic parameters in Gonghu Bay of Lake Taihu, China. Sci. Total Environ., 2010, 409: 314-325.

27.    Chen J, Xie P*, Li L, Xu J. First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage. Toxicol. Sci., 2009, 108: 81-89.

28.    Chen J, Zhang DW, Xie P*, Wang Q, Ma ZM. Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms. Sci. Total Environ., 2009, 407: 3317-3322.

29.    Chen J, Xie P*. Microcystin accumulation in freshwater bivalves from Lake Taihu, China and the potential risk to human consumption. Environ. Toxicol. Chem., 2007, 26: 160-167.

30.    Chen J, Xie P*, Zhang DW, Lei HH. In situ studies on the distribution patterns and dynamics of microcystins in a biomanipulation fish - bighead carp (Aristichthys nobilis). Environ. Pollut., 2007, 147: 150-157.

31.    Chen J, Xie P*, Zhang DW, Ke ZX, Yang H. In situ studies on the bioaccumulation of microcystins in the phytoplanktivorous silver carp (Hypophthalmichthys molitrix) stocked in Lake Taihu with dense toxic Microcystis blooms. Aquaculture, 2006, 261: 1026-1038.

32.    Chen J, Xie P*, Guo LG, Zheng L. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China. Environ. Pollut., 2005, 134: 423-430.

33.    Chen J, Xie P*. Seasonal dynamics of the hepatotoxic microcystins in various organs of four freshwater bivalves from the large eutrophic Lake Taihu of subtropical China and the risk to human consumption. Environ. Toxicol., 2005, 20: 572-584.

34.    Chen J, Xie P*. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China. Toxicon, 2005, 45: 615-625.