导师队伍
| 职 称： | 研究员 |
|---|---|
| 学 历： | 博士研究生 |
| 联系方式： | 86-27-68780078 |
| 电子邮件： | hanhuahu#ihb.ac.cn(请改#为@) |
| 办 公 室： | 1号实验楼415 |
| 个人网页： |
简历介绍：
2001年于中国科学院水生生物研究所取得博士学位，同年8月到厦门大学生命科学学院工作。2002年1月至2004年2月在中国科学院过程工程研究所生化工程国家重点实验室从事博士后研究。2008年1月至2010年1月在法国巴黎高师（école normale supérieure）生物系植物分子生物学实验室作访问学者/博士后。2004年3月起历任中国科学院水生生物研究所副研究员和研究员。曾任中国藻类学会理事（2003年11月-2007年10月）。2015年起兼任法国Université du Maine à Le Mans客座教授（Guest Professor）。
主要以三角褐指藻为模式研究硅藻对环境的适应策略及利用硅藻产油的生物技术。建立了一种简单的电穿孔转化三角褐指藻的方法（Marine Genomics, 2014），与人合作阐明了硅藻尿素循环及其生态意义（Nature, 2011），揭示了氮限制下来自支链氨基酸降解与细胞质糖酵解的碳流导致了硅藻细胞油脂的积累（Plant Cell, 2014），提出了促进硅藻油脂产率有效增加的遗传改良策略（Algal Research, 2015; Philosophical Transactions of the Royal Society B, 2017）。先后主持国家自然科学基金、国家重点基础研究发展计划和科技基础性工作专项子课题等。在Nature、Plant Cell、Plant Journal、Progress in Lipid Research、Marine Pollution Bulletin等知名期刊发表学术论文60多篇，取得授权专利一项。
研究方向：
硅藻生物学
1. Rastogi A, Vieira FRJ, Deton-Cabanillas A-F, Veluchamy A, Cantrel C, Wang G, Vanormelingen P, Bowler C, Piganeau G, Hu H*, Tirichine L*. A genomics approach reveals the genetic polymorphism, structure and functional diversity of ten accessions of the diatom Phaeodactylum tricornutum. The ISME Journal. 2020, 14: 347-363.（*示通讯作者）
2. Chen Y, Hu H*. High efficiency transformation by electroporation of the freshwater alga Nannochloropsis limnetica. World Journal of Microbiology & Biotechnology. 2019, 35(8): 119.
3. Li X, Pan Y, Hu H*. Identification of the triacylglycerol lipase in the chloroplast envelope of the diatom Phaeodactylum tricornutum. Algal Research. 2018, 33: 440-447.
4. Pan Y, Yang J, Gong Y, Li X, Hu H*. 3-hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum. Philosophical Transactions of the Royal Society B‐Biological Sciences. 2017, 372(1728): 20160409.
5. Schoefs B*, Hu H*, Kroth PG*. The peculiar carbon metabolism in diatoms. Philosophical Transactions of the Royal Society B‐Biological Sciences. 2017, 372(1728): 20160405.
6. Wei L, Xin Y, Wang Q, Yang J, Hu H*, Xu J*. RNAi-based targeted gene-knockdown in the model oleaginous microalgae Nannochloropsis oceanica. The Plant Journal. 2017, 89(6): 1236-1250.
7. Yang J, Pan Y, Bowler C, Zhang L, Hu H*. Knockdown of phosphoenolpyruvate carboxykinase increases carbon flux to lipid synthesis in Phaeodactylum tricornutum. Algal Research. 2016, 15: 50-58.
8. Ge F, Huang W, Chen Z, Zhang C, Xiong Q, Bowler C, Yang J, Xu J, Hu H*. Methylcrotonyl-CoA carboxylase regulates triacylglycerol accumulation in the model diatom Phaeodactylum tricornutum. The Plant Cell. 2014, 26(4): 1681-1697.
9. Zhang C, Hu H*. High-efficiency nuclear transformation of the diatom Phaeodactylum tricornutum by electroporation. Marine Genomics. 2014, 16: 63-66.
10. Gong Y, Hu H*. Effect of silicate and inorganic carbon availability on the growth and competition of a diatom and two red-tide dinoflagellates. Phycologia. 2014, 53(5): 433-442.
11. Li F, Gao D, Hu H*. High-efficiency nuclear transformation of the oleaginous marine Nannochloropsis species using PCR product. Bioscience Biotechnology and Biochemistry. 2014, 78(5): 812-817.
12. Gong Y, Wan X, Jiang M, Hu C, Hu H, Huang F. Metabolic engineering of microorganisms to produce omega-3 very long-chain polyunsaturated fatty acids. Progress in Lipid Research. 2014, 56: 19-35.
13. Xu J, Hu H*. Screening high oleaginous Chlorella strains from different climate zones. Bioresource Technology. 2013, 144: 637-643.
14. Zha S, Xu X, Hu H*. A high sensitivity iron-dependent bioreporter used to measure iron bioavailability in freshwaters. FEMS Microbiology Letters. 2012, 334(2): 135-142.
15. Chen Z, He C, Hu H*. Temperature responses of growth, photosynthesis, fatty acid and nitrate reductase in Antarctic and temperate Stichococcus. Extremophiles. 2012, 16(1): 127-133.
16. Allen AE, Dupont CL, Oborník M, Horák A, Nunes-Nesi A, McCrow JP, Zheng H, Johnson DA, Hu H, Fernie AR, Bowler C. Evolution and metabolic significance of the urea cycle in photosynthetic diatoms. Nature. 2011, 473(7346): 203-207.
17. Hu H*, Zhang J, Chen W. Competition of bloom-forming marine phytoplankton at low nutrient concentrations. Journal of Environmental Sciences. 2011, 23(4): 656-663.
18. Maumus F, Allen AE, Mhiri C, Hu H, Jabbari K, Vardi A, Grandbastien M-A, Bowler C. Potential impact of stress activated retrotransposons on genome evolution in a marine diatom. BMC Genomics. 2009, 10: 624.
19. Hu H*, Li H, Xu X. Alternative cold response modes in Chlorella (Chlorophyta, Trebouxiophyceae) from Antarctica. Phycologia. 2008, 47(1): 28-34.
20. Zhang X, Hu H*, Tan T. Photosynthetic inorganic carbon utilization of gametophytes and sporophytes of Undaria pinnatifida (Phaeophyceae). Phycologia. 2006, 45(6): 642-647.
21. Hu H*, Chen W, Shi Y, Cong W. Nitrate and phosphate supplementation to increase toxin production by the marine dinoflagellate Alexandrium tamarense. Marine Pollution Bulletin. 2006, 52(7): 756-760.
22. Hu H*, Gao K. Response of growth and fatty acid compositions of Nannochloropsis sp. to environmental factors under elevated CO2 concentration. Biotechnology Letters. 2006, 28(13): 987-992.
23. Hu H*, Shi Y, Cong W. Improvement in growth and toxin production of Alexandrium tamarense by two-step culture method. Journal of Applied Phycology. 2006, 18(2): 119-126.
24. Shi Y, Hu H*, Cong W. Positive effects of continuous low nitrate levels on growth and photosynthesis of Alexandrium tamarense (Gonyaulacales, Dinophyceae). Phycological Research. 2005, 53(1): 43-48.
25. Shi Y, Hu H*, Ma R, Cong W, Cai Z. Improved use of organic phosphate by Skeletonema costatum through regulation of Zn2+ concentrations. Biotechnology Letters. 2004, 26(9): 747-751.
26. Hu H*, Shi Y, Cong W, Cai Z. Growth and photosynthesis limitation of marine red tide alga Skeletonema costatum by low concentrations of Zn2+. Biotechnology Letters. 2003, 25(22): 1881-1885.
27. Hu H, Gao K. Optimization of growth and fatty acid composition of a unicellular marine picoplankton, Nannochloropsis sp., with enriched carbon sources. Biotechnology Letters. 2003, 25(5): 421-425.