迄今以第一作者或通讯作者发表SCI论文50篇（影响因子>3），其中Environmental Science & Technology发表10篇（影响因子：7.864），Environmental Science & Technology Letters发表1篇（影响因子：7.678）。研究成果受到美国 “Environmental Health News”、新华社、中科院之声等科学媒体的关注和报导，并被挪威环保局采用、作为污染物风险评估的主要依据。

Environmental Science & Technology:

1. Hu, C., Liu, M., Wan, T., Tang, L., Sun, B., Zhou, B., Lam, J.C.W., Lam, P.K.S., Chen, L.* Disturbances in microbial and metabolic communication across the gut-liver axis induced by a dioxin-like pollutant: An integrated metagenomics and metabolomics analysis. Environmental Science & Technology 2020, 55, 529−537.

2. Chen, L.,* Lam, J.C.W., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B.* Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental Science & Technology 2020, 54, 7494−7503.

3. Chen, L.,* Tsui, M.M.P., Hu, C., Wan, T., Au, D.W.T., Lam, J.C.W., Lam, P.K.S., Zhou, B. Parental exposure to perfluorobutanesulfonate impairs offspring development through inheritance of paternal methylome. Environmental Science & Technology 2019, 53, 12018−12025.

4. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Lam, P.K.S., Zhou, B. Perfluorobutanesulfonate exposure skews sex ratio in fish and transgenerationally impairs reproduction. Environmental Science & Technology 2019, 53, 8389−8397.

5. Chen, L., Hu, C., Tsui, M.M.P., Wan, T., Peterson, D.R., Shi, Q., Lam, P.K.S., Au, D.W.T., Lam, J.C.W.,* Zhou, B.* Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology 2018, 52, 4432–4439.

6. Chen, L., Zhang, W.,^# Hua, J., Hu, C., Lai, N.L.S., Qian, P.Y., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysregulation of intestinal health by environmental pollutants: Involvement of the estrogen receptor and aryl hydrocarbon receptor. Environmental Science & Technology 2018, 52, 2323–2330.

7. Chen, L., Au, D.W.T., Hu, C., Peterson, D.R., Zhou, B.,* Qian, P.Y.* Identification of molecular targets for 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in teleosts: New insight into mechanism of toxicity. Environmental Science & Technology 2017, 51, 1840–1847.

8. Chen, L., Zhang, W., Ye, R., Hu, C., Wang, Q., Seemann, F., Au, D.W.T., Zhou, B., Giesy, J.P., Qian, P.Y.* Chronic exposure of marine medaka (Oryzias melastigma) to 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) reveals its mechanism of action in endocrine disruption via the hypothalamus-pituitary-gonadal-liver (HPGL) axis. Environmental Science & Technology 2016, 50, 4492–4501.

9. Chen, L., Sun, J.,^# Zhang, H., Au, D.W.T., Lam, P.K.S., Zhang, W., Bajic, V.B., Qiu, J.W., Qian, P.Y.* Hepatic proteomic responses in marine medaka (Oryzias melastigma) chronically exposed to antifouling compound butenolide [5-octylfuran-2(5H)-one] or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Environmental Science & Technology 2015, 49, 1851–1859.

10. Chen, L., Yu, K.,^# Huang, C., Yu, L., Zhu, B., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 2012, 46, 9727–9734.

Environmental Science & Technology Letters:

11. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Wang, Q., Giesy, J.P., Lam, P.K.S. Perfluorobutanesulfonate exposure causes durable and transgenerational dysbiosis of gut microbiota in marine medaka. Environmental Science & Technology Letters 2018, 5, 731–738.

Environmental Pollution:

12. Tang, L., Liu, M., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos. Environmental Pollution 2020, 266, 115284.

13. Liu, M., Song, S., Hu, C., Tang, L., Lam, J.C.W., Lam, P.K.S., Chen, L.* Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish. Environmental Pollution 2020, 265, 114832.

14. Sun, Y.,^# Tang, L.,^# Liu, Y., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish. Environmental Pollution 2019, 255, 113357.

15. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Wang, Q., Hu, C., Wai, O.W.H., Zhou, B., Lam, P.K.S. Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments. Environmental Pollution 2019, 245, 218–225.

16. Chen, L., Hu, C., Lai, N.L.S., Zhang, W., Hua, J., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 2018, 240, 17–26.

17. Chen, L., Guo, Y., Hu, C., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution 2018, 234, 307–317.

18. Chen, L., Wang, X., Zhang, X., Lam, P.K.S., Guo, Y., Lam, J.C.W.,* Zhou, B.* Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 2017, 230, 96–106.

19. Chen, L., Zhu, B., Guo, Y., Xu, T., Lee, J.-S., Qian, P.Y., Zhou, B.* High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental Pollution 2016, 214, 324–333.

Science of the Total Environment:

20. Hu, C., Liu, M.,^# Tang, L., Sun, B., Huang, Z., Chen, L.* Probiotic Lactobacillus rhamnosus modulates the impacts of perfluorobutanesulfonate on oocyte developmental rhythm of zebrafish. Science of the Total Environment 2021, 776, 145975.

21. Guo, Y., Chen, L.,^# Wu, J., Hua, J., Yang, L., Wang, Q., Zhang, W., Lee, J.S., Zhou, B.* Parental co-exposure to bisphenol A and nano-TiO₂ causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring. Science of the Total Environment 2019, 650, 557–565.

22. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S. Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors. Science of the Total Environment 2019, 660, 136–144.

Chemosphere:

23. Hu, C., Tang, L., Liu, M., Lam, P.K.S., Lam, J.C.W.,* Chen, L.* Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology. Chemosphere 2020, 258, 127409.

24. Tang, L., Song, S., Hu, C., Liu, M., Lam, P.K.S., Zhou, B., Lam, J.C.W., Chen, L.* Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish. Chemosphere 2020, 256, 127169.

25. Zhu, B.,* He, W., Yang, F., Chen, L.* High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo. Chemosphere 2020, 244, 125468.

26. Chen, L.,* Hu, C., Guo, Y., Shi, Q., Zhou, B. TiO₂ nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure. Chemosphere 2019, 217, 732–741.

27. Chen, L., Xu, Y., Wang, W., Qian, P.Y.* Degradation kinetics of a potent antifouling agent, butenolide, under various environmental conditions. Chemosphere 2015, 119, 1075–1083.

Ecotoxicology and Environmental Safety:

28. Hu, C., Huang, Z., Liu, M., Sun, B., Tang, L., Chen, L.* Shift in skin microbiota and immune functions of zebrafish after combined exposure to perfluorobutanesulfonate and probiotic Lactobacillus rhamnosus. Ecotoxicology and Environmental Safety 2021, 218, 112310.

29. Liu, M., Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish. Ecotoxicology and Environmental Safety 2021, 214, 112107.

30. Shi, Q., Tsui, M.M.P., Hu, C., Lam, J.C.W., Zhou, B., Chen, L.* Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae. Ecotoxicology and Environmental Safety 2019, 179, 119–126.

31. Tsui, M.M.P., Chen, L.,^# He, T., Wang, Q., Hu, C., Lam, J.C.W., Lam, P.K.S.* Organic ultraviolet (UV) filters in the South China sea coastal region: Environmental occurrence, toxicological effects and risk assessment. Ecotoxicology and Environmental Safety 2019, 181, 26–33.

Aquatic Toxicology:

32. Liu, M., Tang, L., Hu, C., Huang, Z., Sun, B., Lam, J.C.W., Lam, P.K.S., Chen, L.* Antagonistic interaction between perfluorobutanesulfonate and probiotic on lipid and glucose metabolisms in the liver of zebrafish. Aquatic Toxicology 2021

33. Chen, L.* Visual system: an understudied target of aquatic toxicology. Aquatic Toxicology 2020, 225, 105542.

34. Tang, L., Liu, M., Song, S., Hu, C., Lam, P.K.S., Lam, J.C.W., Chen, L.* Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos. Aquatic Toxicology 2020, 222, 105466.

35. Chen, L., Tsui, M.M.P., Shi, Q., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S.,* Lam, J.C.W.* Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure. Aquatic Toxicology 2018, 201, 1–10.

36. Chen, L., Au, D.W.T., Hu, C., Zhang, W., Zhou, B., Cai, L., Giesy, J.P., Qian, P.Y.* Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3′-diindolylmethane (DIM). Aquatic Toxicology 2017, 183, 135–143.

37. Chen, L., Ye, R., Xu, Y., Gao, Z., Au, D.W.T., Qian, P.Y.* Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquatic Toxicology 2014, 149, 116–125.

38. Chen, L., Zhang, H.,^# Sun, J., Wong, Y.H., Han, Z., Au, D.W.T., Bajic, V.B., Qian, P.Y.* Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Aquatic Toxicology 2014, 157, 47–56.

39. Chen, L., Hu, C., Huang, C., Wang, Q., Wang, X., Yang, L., Zhou, B.* Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 2012, 120–121, 11–18.

Journal of Environmental Sciences:

40. Liu, M., Sun, Y.,^# Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Fingerprinting fecal DNA and mRNA as a non-invasive strategy to assess the impact of polychlorinated biphenyl 126 exposure on zebrafish. Journal of Environmental Sciences 2021, 106, 15–25.

41. Chen, L.,* Lam, J.C.W. SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern. Journal of Environmental Sciences 2017, 61, 68–79.

Chemical Research in Toxicology:

42. Tang, L., Song, S., Hu, C., Lam, J.C.W., Liu, M., Zhou, B., Lam, P.K.S., Chen, L.* Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish. Chemical Research in Toxicology 2020, 33, 1605–1608.

43. Chen, L., Ye, R., Zhang, W., Hu, C., Zhou, B., Peterson, D.R., Au, D.W.T., Lam, P.K.S., Qian, P.Y.* Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (HPGL) axis in marine medaka (Oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3'-diindolylmethane (DIM). Chemical Research in Toxicology 2016, 29, 1020–1028.

Marine Pollution Bulletin:

44. Chen, L., Lam, J.C.W., Zhang, X., Pan, K., Guo, C., Lam, P.K.S, Wang, W., Liu, H., Qian, P.Y.* Relationship between metal and polybrominated diphenyl ether (PBDE) body burden and health risks in the barnacle Balanus amphitrite. Marine Pollution Bulletin 2015, 100, 383–392.

Environmental Toxicology and Chemistry:

45. Chen, L., Huang, C., Hu, C., Yu, K., Yang, L., Zhou, B.* Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology and Chemistry 2012, 31, 2338–2344.

46. Chen, L., Huang, Y., Huang, C., Hu, B., Hu, C., Zhou, B.* Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environmental Toxicology and Chemistry 2013, 32, 1370–1375.

Progress in Organic Coatings:

47. Chen, L., Xia, C., Qian, P.Y.* Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests. Progress in Organic Coatings 2017, 109, 22–29.

Marine Drugs:

48. Chen, L., Qian, P.Y.* Review on molecular mechanisms of antifouling compounds: An update since 2012. Marine Drugs 2017, 15, 264.

Toxics:

49. Chen, L.* Gut microbiota manipulation to mitigate the detrimental effects of environmental pollutants. Toxics 2021, 9, 127.

Environmental Toxicology and Pharmacology:

50. Xu, T., Chen, L.,* Hu, C., Zhou, B. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environmental Toxicology and Pharmacology 2013, 35, 13–20.