个人简介

谢海侠，女，博士，研究员。1999年获华中农业大学学士学位，2005年获中国科学院水生生物研究所博士学位。2005-2007年于新加坡国立大学生物系接受博士后培训。2017-2018年于帝国理工学院微生物系开展合作交流。

研究重点为水产细菌性病原的分子致病机理及其免疫预防。主要研究方向包括：

1、 水产细菌性病原与宿主的相互作用;

2、 水产细菌性病原生物被膜(biofilm)的形成及干预;

3、 水产细菌性病原的浸泡疫苗的研制

招生专业：水生生物学

招生方向：病原微生物学

代表性论文(* 通讯作者，# 并列作者)

Zhang Qian#, He Tian Tian#, Li Duan You, Nie Pin*, Xie Hai Xia*. The Edwardsiella piscicida type III effector EseJ suppresses expression of type 1 fimbriae, leading to decreased bacterial adherence to host cells. Infection & Immunity, 2019, 87: e00187-19.

Liu Ying Li, He Tian Tian, Liu Lu Yi, Yi Jia, Nie Pin, Yu Hong Bing, Xie Hai Xia*. The Edwardsiella piscicida type III translocon protein EseC inhibits biofilm formation by sequestering EseE. Applied and Environmental Microbiology 2019, 85:e02133-18.

Wang Gai Ling, Wang Ming Cheng, Liu Ying Li, Zhang Q, Li Chuan Feng, Liu Pan Ting, Li En Zhong, Nie Pin, Xie Hai Xia*. Identification, expression analysis, and antibacterial activity of NK-lysin from common carp Cyprinus carpio. Fish & Shellfish Immunology, 2018, 73:11-21.

Wang Gai Ling, Wang Ming Cheng, Zhang Xiao Wen, Chang Ming Xian, Xie Hai Xia*, Nie Pin. Molecular cloning, biological effect, and tissue distribution of interleukin-8 protein in mandarin fish (Siniperca chuasti) upon Flavobacterium columnare infection. Fish & Shellfish Immunology, 2017, 66:112-119.

Liu Lu Yi, Nie Pin*, Yu Hong Bing, Xie Hai Xia*. Regulation of type III secretion of translocon and effector proteins by the EsaB/EsaL/EsaM complex in Edwardsiella tarda. Infection & Immunity, 2017, 85:e00322-17.

Zhou Ying, Liu Lu Yi, He Tian Tian, Laghari Zubair Ahmed, Nie Pin, Gao Qian, Xie Hai Xia*. Edwardsiella tarda EsaE (Orf19 protein) is required for the secretion of type III substrates, and pathogenesis in fish. Veterinary Microbiology, 2016, 190:12-18.

Yi Jia, Xiao Shui Bing, Zeng Zhi Xiong, Lu Jin Fang, Liu Lu Yi, Laghari Zubair Ahmed, Nie Pin, Yu Hong Bing, Xie Hai Xia*. EseE of Edwardsiella tarda augments the secretion of translocon protein EseC and the expression of escC-eseE operon. Infection & Immunity 2016, 84:2336-2344.

Lu Jin Fang, Wang Wei Na, Wang Gai Ling, Zhang He, Zhou Ying, Gao Zhi Peng, Nie Pin*, Xie Hai Xia*. Edwardsiella tarda EscE (Orf13 protein) is a type III secretion system secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection & Immunity 2016, 84:2-10.

Gao Zhi Peng, Nie Pin, Lu Jin Fang, Liu Lu Yi, Xiao Tiao Yi, Liu Wei, Liu Jia Shou*, Xie Hai Xia*. Type III secretion system translocon component EseB forms filaments and mediates autoaggregation and biofilm formation in Edwardsiella tarda. Applied and Environmental Microbiology 2015, 81:6078-6087.

Xie Hai Xia#, Lu Jin Fang#, Zhou Ying, Yi Jia, Yu Xiu-Jun*, Leung Ka Ying, Nie Pin*. Identification and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection & Immunity 2015, 83:1650-1660.

Xie Hai Xia, Lu Jin Fang, Rolhion Nathalie, Holden David W., Nie Pin*, Zhou Ying, Yu Xiu-Jun*. Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infection & Immunity 2014, 82:3436-3445.

Zhao Li Juan, Lu Jin Fang, Nie Pin*, Li Ai Hua, Xiong Bang Xi, Xie Hai Xia*. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology 2013, 166:233-41.

Xie Hai Xia, Yu Hong Bing, Zheng Jun, Foster Leonard J., Mok Yu-Keung, Finlay Brett B., Nie Pin, Leung Ka Yin*. EseG, an effector of the type III secretion system of Edwardsiella tarda triggers microtubule destabilization. Infection & Immunity 2010, 78:5011-5021.