我们构建的斑马鱼NPC1疾病模型克服了以往的动物模型的一个重要缺陷，即不易得到大量生存周期较长（超过6个月）的纯合个体这样一个弊病。因此，该模型非常适合进行深入的机制研究及大规模的药物筛选。文章发表以后，受到国际同行的高度关注。匈牙利的制药公司Cyclolab Ltd.（成立于1972年）主动联系作者，要求合作进行药物筛选。

代表性论文：

1. X.D. Hu, B. Wang, H.H. Feng, M. Zhou, Y.S. Lin and H. Cao*. Protein phosphatase PP1 negatively regulates IRF3 in response to GCRV infection in grass carp (Ctenopharyngodon idella), Frontiers in Immunology, 2021, 11:609890.

2. B. Wang, M. Zhou, Y.S. Lin, Y.G. Ma and H. Cao*. TBK1 regulates the induction of innate immune response against GCRV by phosphorylating IRF3 in rare minnow (Gobiocypris rarus), Developmental and Comparative Immunology, 2021, 115, 103883.

3. M. Zhou, B. Wang, Y.S. Lin, C. Zhang and H. Cao*. Molecular cloning, functional characterization and expression analysis of P65 subunit in response to GCRV infection in rare minnow (Gobiocypris rarus), Developmental and Comparative Immunology, 2020, 113, 103786.

4. Y.S. Lin, X.L. Cai, G.P. Wang, G. Ouyang and H. Cao*. Model construction of Niemann-Pick type C disease in zebrafish，Biological Chemistry, 2018, 399(8): 903-910.

5. J. Wang, X. Q. Leng, G. P. Wang, X. Y. Wan and H. Cao*. The construction of intrahepatic cholangiocarcinoma model in zebrafish, Scientific Reports, 2017, 7, 13419.