2003-2007年 武汉大学 生命科学学院 理学学士

2008-2013年 中国科学院水生生物研究所 遗传学专业 理学博士

2013-2016年 中国科学院水生生物研究所 助理研究员

2017-2024年 中国科学院水生生物研究所 副研究员

2025年至今  中国科学院水生生物研究所研究员

遗传学（硕士生，博士生）

1. 鱼类耐低氧的遗传机制解析与耐低氧新品种培育

2. 鱼类抗病毒感染的遗传机制解析与抗病新品种培育

3. 鱼类耐低氧性状和抗病性状耦合的遗传机制解析与复合优良性状新品种培育

1. 2023.12-2028.11  中国科学院战略性先导专项项目：水产动物重要病毒病的新型防控技术原理，3139.54万元，主持

2. 2023.01-2026.12  国家自然科学基金面上项目：甲基转移酶set7/9在鱼类抗病毒先天免疫中的作用机制，70.2万，主持

3. 2022.12-2027.11  国家重点研发计划：重要养殖鱼、虾高产和抗病性状形成的分子调控网络研究，200万，子课题负责人

4. 2022.10-2025.09  湖北省自然科学基金杰出青年基金项目：鱼类抗逆抗病的遗传育种，30万，主持

5. 2017.01-2020.12  中国科学院青年创新促进会人才专项，80万，主持

聚焦于鱼类耐低氧性状和抗病性状的遗传机制解析，开展了系统的研究工作，发表论文60余篇，以第一发明人授权发明专利3项。其中，近5年来以第一作者或通讯作者发表的代表性论文如下：

(1) Zixuan Wang^#, Xiaoyun Chen^#, Chunchun Zhu, Sijia Fan, Jinhua Tang, Hongyan Deng, Xueyi Sun, Xing Liu*, Wuhan Xiao*. Direct lysine demethylation of IRF3 by the methytransferase SMYD3 attenuates antiviral innate immunity. PNAS, 2025, 122 (3): e2320644122.

(2) Xing Liu^#, Chunchun Zhu^#, Shuke Jia, Hongyan Deng, Jinhua Tang, Xueyi Sun, Xiaoli Zeng, Xiaoyun Chen, Zixuan Wang, Wen Liu, Qian Liao, Huangyuan Zha, Xiaolian Cai, Wuhan Xiao*. Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity. PNAS, 2024, 121 (17): e2314201121.

(3) Xing Liu^#, Jinhua Tang^#, Zixuan Wang^#, Chunchun Zhu, Hongyan Deng, Xueyi Sun, Guangqing Yu, Fangjing Rong, Xiaoyun Chen, Qian Liao, Shuke Jia, Wen Liu, Huangyuan Zha, Sijia Fan, Xiaolian Cai, Jian-Fang Gui, Wuhan Xiao*. Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3. Nature Communications, 2024, 15(1): 3533.

(4) Xing Liu^#, Chunchun Zhu^#, Huanyuan Zha, Jinhua Tang, Fanjing Rong, Xiaoyun Chen, Sijia Fan, Chenxi Xu, Juan Du, Junji Zhu, Jing Wang, Gang Ouyang, Guangqing Yu, Xiaolian Cai, Zhu Chen, Wuhan Xiao*. SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO Journal, 2020, 39 (11): e103285.

(5) Xueyi Sun, Wen Liu, Chunchun Zhu, Zixuan Wang, Hongyan Deng, Qian Liao, Wuhan Xiao*, Xing Liu*, Genetic evidence for the suppressive role of zebrafish vhl targeting mavs in antiviral innate immunity during RNA virus infection, Journal of Immunology, 2025, 214(1): 167-179.

(6)  Wen Liu, Xueyi Sun, Chunchun Zhu, Zixuan Wang, Hongyan Deng, Wuhan Xiao*, Xing Liu*, Ctenopharyngodon idella (grass carp) pVHL suppresses antiviral innate immunity by targeting MAVS for degradation upon GCRV infection, Aquaculture, 2025, 600: 742274.

(7) Yao Bai, Qian Liao, Zixuan Wang, Chunchun Zhu, Wen Liu, Wuhan Xiao*, Xing Liu*, Ctenopharyngodon idella (grass carp) SIRT7 negatively regulates anti-GCRV innate immunity by promoting IRF3 and IRF7 degradation, Aquaculture, 2025, 606: 742575.

(8) Chunchun Zhu, Wen Liu, Shuke Jia, Xueyi Sun, Zixuan Wang, Hongyan Deng, Yao Bai, Wuhan Xiao*, Xing Liu*, Grass carp (Ctenopharyngodon idella) SIRT3 enhances MAVS-mediated antiviral innate immunity in response to GCRV infection, Aquaculture, 2024, 587: 740871.

(9) Zixuan Wang, Chunchun Zhu, Xueyi Sun, Hongyan Deng, Wen Liu, Shuke Jia, Yao Bai,Wuhan Xiao*, Xing Liu*. Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α. Journal of Virology, 2024, e149124.

(10) Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li*,Wuhan Xiao*, Xing Liu*. SET7 methylates the deubiquitinase OTUB1 at Lys122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis. Journal of Biological Chemistry, 2023, 299 (4): 103054.

(11) Qian Liao^#, Hongyan Deng^#, Zixuan Wang, Guangqing Yu, Chunchun Zhu, Shuke Jia, Wen Liu, Yao Bai, Xueyi Sun, Xiaoyun Chen,Wuhan Xiao*, Xing Liu*, Deletion of prolyl hydroxylase 3 (phd3) in zebrafish facilitates hypoxia tolerance. Journal of Biological Chemistry, 2023, 299 (12): 105420.

(12) Qian Liao, Chunchun Zhu, Xueyi Sun, Zixuan Wang, Xiaoyun Chen, Hongyan Deng, Jinhua Tang, Shuke Jia, Wen Liu,Wuhan Xiao*, Xing Liu*. Disruption of sirtuin 7 in zebrafish facilities hypoxia tolerance. Journal of Biological Chemistry, 2023, 299 (8): 105074.

(13) Xueyi Sun, Chunchun Zhu, Wen Liu, Zixuan Wang, Hongyan Deng, Shuke Jia, Yao Bai, Wuhan Xiao*, Xing Liu*, Loss of one copy of vhl in zebrafish facilitates hypoxia tolerance, Aquaculture Reports, 2023, 33: 101782.

(14) Xueyi Sun, Chunchun Zhu, Wen Liu, Zixuan Wang, Xiaoyun Chen, Yao Bai, Wuhan Xiao*, Xing Liu*, Molecular characterization and expression of Megalobrama amblycephala (Wuchang bream) lysine monomethylase set7 and its potential role in hypoxia adaptation, Aquaculture Reports, 2023, 33: 101774.

(15) Zixuan Wang, Chunchun Zhu, Xiaoyun Chen, Hongyan Deng, Xueyi Sun, Qian Liao, Shuke Jia, Wen Liu, Yao Bai, Wuhan Xiao*, Xing Liu*, Oxygen potentiates antiviral ability of zebrafish in response to SVCV infection, Water Biology and Security, 2023, 2(4): 100207.

(16) Xing Liu^#, Fangjing Rong^#, Jinhua Tang, Chunchun Zhu, Xiaoyun Chen, Shuke Jia, Zixuan Wang, Xueyi Sun, Hongyan Deng, Huangyuan Zha, Gang Ouyang,Wuhan Xiao*. Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage. Cell Death & Differentiation, 2022, 29(4): 722-736.

(17) Jinhua Tang, Hongyan Deng, Zixuan Wang, Huanyuan Zha, Qian Liao, Chunchun Zhu, Xiaoyun Chen, Xueyi Sun, Shuke Jia, Gang Ouyang, Xing Liu*, Wuhan Xiao*. EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1αis repressed by SET7-catalyzed lysine methylation. Journal of Biological Chemistry, 2022, 298(6): 101961.

(18) Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Qian Liao, Jinhua Tang, Guangqing Yu, Xiaolian Cai, Gang Ouyang, Wuhan Xiao*, Xing Liu*. Zebrafish sirt5 negatively regulates antiviral innate immunity by attenuating phosphorylation and ubiquitination of mavs. Journal of Immunology, 2022, 209(6): 1165-1172.

(19) Xing Liu^#, Hongyan Deng^#, Jinhua Tang, Zixuan Wang, Chunchun Zhu, Xiaolian Cai, Fangjing Rong, Xiaoyun Chen, Xueyi Sun, Shuke Jia, Gang Ouyang, Wenhua Li*,Wuhan Xiao*. OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1αduring hypoxia adaptation. Cell Death & Disease, 2022, 13(6): 560.

(20) Zixuan Wang, Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Hongyan Deng, Jinhua Tang, Xueyi Sun, Shuke Jia, Qian Liao,Wuhan Xiao*, Xing Liu*. Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity. Journal of Biological Chemistry, 2022, 292(12): 102633.

(21) 查荒源, 于光晴, 陈小云, 肖武汉*, 刘兴*. 甲基转移酶set9缺失的斑马鱼低氧耐受能力增强, 水生生物学报，2021, 45, 951-957.

2020年获中国科学院水生生物研究所“科研青年学者”荣誉称号；

2020年获中国科学院水生生物研究所杰出创新奖；

2021年获中国科学院水生生物研究所杰出创新奖。

湖北省遗传学会理事

参与指导的研究生多人次获得国家奖学金、中国科学院院长优秀奖等奖项。

欢迎有遗传学、免疫学、水产养殖学背景的考生报考。