通过以上课题的研究，建立了涵盖活体测试、离体测试和计算机模拟等手段的毒性效应评价体系，获得了长江中上游多个河流、湖泊中重金属和有机污染物的监测数据，并评价了典型污染物对水生态系统的潜在风险。共发表学术论文50余篇，其中第一或（共同）通讯作者SCI论文20余篇，第一或通讯作者中文核心期刊6篇，参与编写专著1部（排名第二）。

代表性论文：

[1]  Yang Lihua#, Zhang Yindan#, Hua Jianghuan*, Song Guili, Li Fan, Zheng Na, Zhang Taotao, Xu Zhixiang, Ren Xinxin, Zhu Biran, Han Yanna, Guo Yongyong, Han Jian, Zhou Bingsheng*, Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro, Environmental Health Perspectives, 2024, 132: 117005.

[2]  Yang Lihua, Zhu Biran, Zhou Shanqi, Zhao Min, Li Ruiwen, Zhou Yuxi, Shi Xiongjie, Han Jian, Zhang Wei, Zhou Bingsheng: Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae. Environmental Science & Technology 2023, 57, 11043-11055. [3]  Zheng Na, Wang Xiaochen, Zhang Yindan, Hua Jianghuan, Zhu Biran, Zhou Yuxi, Xu Zhixiang, Luo Lijun, Han Jian, Yang Lihua*, Zhou Bingsheng, Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy)ethane-Induced Male Reproductive Toxicity in Zebrafish, Environmental Science & Technology, 2024, 58: 8251-8263.

[4] Fu Kaiyu, Zhu Biran, Sun Yumiao, Zhou Yuxi, Pang Hao, Ren Xinxin, Guo Yongyong, Shi Xiongjie, Han Jian, Yang Lihua*, Zhou Bingsheng: Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver. Environmental Science & Technology 2024, 4937-4947.

[5]  Li Fan, Song Guili, Wang Xiaochen, Sun Yumiao, Zhou Shanqi, Zhang Yindan, Hua Jianghaun, Zhu Biran, Yang Lihua*, Zhang Wei, Zhou Bingsheng: Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane. Environmental Science & Technology 2023, 57, 19419-19429.

[6]  Sun Yumiao, Zhou Shanqi, Zhu Biran, Li Fan, Fu Kaiyu, Guo Yongyong, Men Jun, Han Jian, Zhang Wei, Yang Lihua*, Zhou Bingsheng, Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae. Environmental Science & Technology 2023, 57: 2887-2897.

[7]  Sun Yumiao, Wang Xiaochen, Zhou Shanqi, Zhou Yuxi, Hua Jianghuan, Guo Yongyong, Wang Yan, Zhang Wei, Yang Lihua*, Zhou Bingsheng*: Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE). Environmental Science & Technology 2023, 57, 16811-16822.

[8]  Fu Kaiyu, Hua Jianghuan, Zhang Yindan, Du Mingpu, Han Jian, Li Na, Wang Qiangwei, Yang Lihua*, Li Ruiwen*, Zhou Bingsheng: Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo. Environmental Science & Technology 2024, 58: 194-206.

[9]  Zhou Yuxi, Li Fan, Fu Kaiyu, Zhang Yindan, Zheng Na, Tang Huijia, Xu Zhixiang, Luo Lijun, Han Jian, Yang Lihua*, Zhou Bingsheng*: Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver. Environmental Science & Technology 2024, 58: 4581-4593. (SCI, Nature Index, 共同通讯作者; IF5y=11.6; JCR=5%)

[10]       Zhu Biran, Lei Lei, Sun Yumiao, Shi Xiongjie, Fu Kaiyu, Hua Jianghuan, Martyniuk Christopher J., Han Jian*, Yang Lihua*, Zhou Bingsheng, Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish. Environmental Science & Technology 2022, 56: 11516-11526.

[11]       Sun Yumiao, Zhu Biran, Ling Siyuan, Yan Biao, Wang Xiulin, Jia Shuzhao, Martyniuk Christopher J., Zhang Wei, Yang Lihua*, Zhou Bingsheng*: Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish. Environmental Science & Technology 2022, 56(1):470-479.

[12]       Hu Zhichao#, Yang Lihua#, Han Jian, Liu Zishu, Zhao Yuxiang, Jin Yihao, Sheng Yaqi, Zhu Lizhong, Hu, Baolan, Human viruses lurking in the environment activated by excessive use of COVID-19 prevention supplies. Environment International 2022, 163, 107192.

[13]       Liu Sitian, Song Guili, Li Fan, Li Ruiwen, Chen Xiangping, Guo Yongyong, Zhou Fang, Wang Qiangwei, Yang Lihua*, Zhou Bingsheng, Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies. Journal of Hazardous Materials 2022, 424: 127386.

[14]       Sun Yumiao, Wang Xiaochen, Guo Wei, Li Fan, Hua Jianghuan, Zhu Biran, Guo Yongyong, Han Jian, Yang Lihua* Zhou Bingsheng: Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish. Science of the Total Environment 2024, 950: 175337.

[15]       Jianghuan Hua*, Taotao Zhang, Xianglin Chen, Biran Zhu, Min Zhao, Kaiyu Fu, Yindan Zhang, Huijia Tang, Hao Pang, Yongyong Guo, Jian Han, Lihua Yang*, Bingsheng ZhouBehavioral impairments and disrupted mitochondrial energy metabolism induced by polypropylene microplastics in zebrafish larvae. Science of the Total Environment 2024, 947: 174541.

[16]       Zhou Yuxi, Lei Lei, Zhu Biran, Li Ruiwen, Zuo Yanxia, Guo Yongyong, Han Jian, Yang Lihua*, Zhou Bingsheng: Aggravated visual toxicity in zebrafish larvae upon co-exposure to titanium dioxide nanoparticles and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate. The Science of the Total Environment 2024, 921: 171133.

[17]       Chen Xiangping, Lei Lei, Liu Sitian, Han Jian, Li Ruiwen, Men Jun, Li Lin, Wei Lin, Sheng Yaqi, Yang Lihua*, Zhou Bingsheng, Zhu Lizhong: Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China. Science of The Total Environment 2021, 792: 148352.

[18]       Yang Lihua, Zha Jinmiao*, Guo Yongyong, Zhou Bingsheng: Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays. Science of The Total Environment 2020, 716:136987.

[19]      Yang Lihua, Huang Tao, Li Ruiwen, Souders Christopher, Rheingold Spencer, Tischuk Claire, Li Na, Zhou Bingsheng, Martyniuk Christopher J. *: Evaluation and comparison of the mitochondrial and developmental toxicity of three strobilurins in zebrafish embryo/larvae. Environmental Pollution 2020:116277.

[20]       Peng Wei, Liu Sitian, Guo Yongyong, Yang Lihua*, Zhou Bingsheng: Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae. Environmental Pollution 2020, 259:113923.

[21]       Li Ruiwen, Yang Lihua*, Han Jian, Zou Yu, Wang Yingcai, Feng Chenglian, Zhou Bingsheng: Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications. Environmental Pollution 2021, 285:117471.

[22]       Hua Jianghuan, Wang Xiulin, Zhu Jiaping, Wang Qiangwei, Zhang Wei, Lei Lei, Zhu Biran, Han Jian, Yang Lihua*, Zhou Bingsheng, Ecotoxicology and Environmental Safety 2022, 244: 114044.

[23]       Yang Lihua, Ivantsova Emma, Souders Christopher L., Martyniuk Christopher J.: The agrochemical S-metolachlor disrupts molecular mediators and morphology of the swim bladder: Implications for locomotor activity in zebrafish (Danio rerio). Ecotoxicology and Environmental Safety 2021, 208: 111641.

[24]       Wang Xiulin, Sun Yumiao, Fu Mengru, Chen Pengyu, Wang Qiangwei, Hua Jianghuan, Fu Kaiyu, Zhang Wei, Zhu Lifei, Yang Lihua*, Zhou Bingsheng. Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae. Frontiers in Environmental Science 2022, 10, 860786.

[25]       Li Ruiwen, Pang Hao, Guo Yemin, Zhou Xuan, Fu Kaiyu, Zhang Taotao, Han Jian, Yang Lihua*, Zhou Bingsheng, Zhou Si*: Distribution of Polycyclic Aromatic Hydrocarbons and Pesticides in Danjiangkou Reservoir and Evaluation of Ecological Risk. Toxics 2024, 12(12): 859.

[26]       华江环;郭勇勇;宋高飞;李瑞雯;韩建;杨丽华*;周炳升; 南水北调中线总干渠水中酞酸酯类物质含量及风险评价. 生态毒理学报 2022, 17, 354-366.

[27]       郭勇勇, 华江环, 朱宇轩, 宋高飞, 李瑞雯, 韩建, 杨丽华, 周炳升, 南水北调中线总干渠水中重金属含量及风险评价. 水生生物学报2022 

[28]       郭勇勇,杨丽华*,周炳升,倪朝辉,李云峰, 长江上游水体中酞酸酯的污染水平及生态风险评价. 水生生物学报 2019, 43, 62-68.

[29]       郭威,郭勇勇,杨丽华*,周炳升, 长江上游水体中主要污染物的环境分布和风险评价研究进展.水生生物学报 2019, 43, 69-76.

[30]       杨丽华,史奇朋,周炳升*, 双酚A对斑马鱼幼鱼神经递质和神经行为的影响, 生态毒理学报 2017, 12, 162-169.

专著软著：

周炳升，杨丽华，刘春生等，持久性有机污染物的内分泌干扰效应，科学出版社，2018.

杨丽华，周炳升，郭勇勇，长江流域特征污染物基础毒理数据管理系统V1.0（登记号：2024SR1249132）