职 称: | 研究员 |
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学 历: | 博士研究生 |
联系方式: | 027-68780203 |
电子邮件: | zhenxu#ihb.ac.cn(请改#为@) |
办 公 室: | 3号楼8楼 |
个人网页: | http://people.ucas.edu.cn/~zhenxu |
1998.9-2002.7 山东农业大学 水产养殖 学士 2003.9-2006.7 华中农业大学 水产养殖 硕士 2006.9-2009.7 华中农业大学 水产养殖 博士 |
2009.8-2010.1 中国科学院水生生物研究所 科研助理 2010.2-2014.12 美国宾夕法尼亚大学 博士后 2015.1-2021.2 华中农业大学 教授 2021.3-至今 中国科学院水生生物研究所 研究员 |
水产养殖(硕士生),水生生物学(博士生) |
1. 鱼类黏膜免疫分子机制 2. 鱼类黏膜疫苗设计 |
1. 2023.1-2027.12鱼类黏膜免疫,国家杰出青年科学基金,主持 2. 2021.1-2023.12 中国科学院引才计划,现代农业:鱼类黏膜免疫, 主持 3. 2021.1-2024.12 鱼类黏膜B细胞吞噬、抗原递呈功能及其 分子机制的研究, 国家基金面上项目,主持 4. 2019.1-2022.12 鱼类B和T淋巴细胞在细菌感染过程中的免疫应答规律与互作机制的研究, 国家基金面上项目,主持 5. 2018.12-2022.12 水产动物精准营养及其代谢调控机制(水产动物免疫应答的营养调控机制),国家重点研发计划“蓝色粮仓”课题,主持 |
主要从事鱼类黏膜免疫和病害防控的研究,阐明了以IgT为代表的鱼类黏膜免疫球蛋白的功能,揭示了病原诱导的鱼类黏膜免疫应答机制,为研制鱼类黏膜疫苗及抗病育种提供了基础。以第一或通讯(含并列)在Science Immunology、Cell Discovery、Nature Communications、PNAS、Reviews in Aquaculture、PLOS Pathogens、iScience、Journal of Immunology等发表论文50余篇。研究成果被Nature Reviews Immunology等以“研究亮点”(Research Highlights)进行评述。 代表性论文: 1. Yongyao Yu#, Zhenyu Huang#, Weiguang Kong#, Fen Dong#, Xiaoting Zhang, Xue Zhai, Gaofeng Cheng, Mengting Zhan, Jiafeng Cao, Liguo Ding, Guangkun Han, Fumio Takizawa, Yang Ding, J. Oriol Sunyer*, Zhen Xu*. (2022) Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses. Cell Discovery. 2022, 8:31. 2. Jiafeng Cao#, Liguo Ding#, Qingchao Wang#, Guangkun Han, Dacheng Qin, Gaofeng Cheng, Zhaoran Dong, Qingjiang Mu, Weiguang Kong, Xia Liu, Yongyao Yu, Zhen Xu*. (2022) Conserved role of mTORC1 signaling in B cell immunity in teleost fish. Journal of Immunology. 2022, 209(6): 1095-1107. 3. Xiaoting Zhang#, Yongyao Yu#, Haoyue Xu#, Zhenyu Huang, Xia Liu, Jiafeng Cao, Kaifeng Meng, Zhengben Wu, Guangkun Han, Mengting Zhan, Liguo Ding, Weiguang Kong, Nan Li, Fumio Takizawa, J. Oriol Sunyer, Zhen Xu*. (2021) Prevailing role of mucosal Igs and B cells in teleost skin immune responses to bacterial infection. Journal of Immunology. 2021, 206 (5): 1088-1101. 4. Yongyao Yu#, Liguo Ding#, Zhenyu Huang#, Haoyue Xu#, Zhen Xu*. (2021) Commensal bacteria-immunity crosstalk shapes mucosal homeostasis in teleost fish. Reviews in Aquaculture. 2021, 13: 2322-2343. 5. Zhen Xu#, Fumio Takizawa#, Elisa Casadei, Yasuhiro Shibasaki, Yang Ding, Thomas J. C. Sauters, Yongyao Yu, Irene Salinas*, J. Oriol Sunyer*. (2020) Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. Science Immunology. 2020, 5(44): eaay3254. (Cover Story) 6. Yongyao Yu#, Weiguang Kong#, Haoyue Xu, Zhenyu Huang, Xiaoting Zhang, Liguo Ding, Shuai Dong, Guangmei Yin, Fen Dong, Wei Yu, Jiafeng Cao, Kaifeng Meng, Xia Liu, Yu Fu, Xuezhen Zhang, Yongan Zhang, J. Oriol Sunyer, Zhen Xu*. (2019) Convergent evolution of mucosal immune responses at the buccal cavity of teleost fish. iScience. 2019, 19: 821-835. 7. Weiguang Kong#, Yongyao Yu#, Shuai Dong, Zhenyu Huang, Liguo Ding, Jiafeng Cao, Fen Dong, Xiaoting Zhang, Xia Liu, Haoyue Xu, Kaifeng Meng, Jianguo Su, Zhen Xu*. (2019) Pharyngeal immunity in early vertebrates provides functional and evolutionary insight into mucosal homeostasis. Journal of Immunology. 2019, 203(11): 3054-3067. 8. Yongyao Yu#, Weiguang Kong#, Yaxing Yin, Fen Dong, Zhenyu Huang, Guangmei Yin, Shuai Dong, Irene Salinas, Yongan Zhang, Zhen Xu*. (2018) Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection. PLOS Pathogens. 2018, 14(11): e1007251. 9. Zhen Xu, Fumio Takizawa, David Parra, Daniela Gomez, Louise von Gersdorff Jorgensen, Scott E. LaPatra, J. Oriol Sunyer*. (2016) Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Nature Communications. 2016, 7: 10728. 10. Zhen Xu#, David Parra#, Daniela Gomez#, Irene Salinas, Yongan Zhang, Louise von Gersdorff Jorgensen, Rasmus Demuth Heinecke, Kurt Buchmann, Scott LaPatra, J. Oriol Sunyer. (2013) Teleost skin, an ancient mucosal surface that elicits gut-like immune responses. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(32): 13097-13102.
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农业农村部淡水养殖病害防治重点实验室主任 中国水产学会鱼病专业委员会副主任委员 |
欢迎有生物学、免疫学、水产养殖学背景的考生报考。 |