副研究员，硕士生导师。2007年本科毕业于武汉大学生命科学学院;2013年于中国科学院水生生物研究所遗传学专业获博士学位。2013年进入中国科学院水生生物研究所工作任助理研究员，2017年晋升为副研究员。2017年 入选中国科学院青年创新促进会，获得专项人才资助。

　　近年来，主持国家自然科学基金2项，湖北省自然科学基金1项，中国科学院特色所服务项目1项，水生所知识创新人才项目1项。曾荣获中国科学院水生生物研究所青年科技奖、优秀论文奖和中国科学院武汉分院优秀共产党员等荣誉称号。在学术期刊Science，EMBO Journal，Nature Communications，Nucleic Acids Research，PLoS Pathogens，Journal of Biological Chemistry，Journal of Immunology等国际经典SCI上发表论文17篇，其中第一或共同第一作者5篇。

研究方向:

　　1)以斑马鱼作为模式生物，解析鱼类低氧耐受与低氧适应的遗传基础;

　　2)以斑马鱼作为模式生物，解析肿瘤发生和抗病毒天然免疫的分子机制;

　　3)解析低氧信号转导、细胞命运决定和抗病毒天然免疫应答的调控网络。

招生专业: 遗传学

招生方向: 鱼类低氧生物学、分子细胞生物学

　　[1] Zeshan Lin#, Lei Chen#, Xianqing Chen#, Yingbin Zhong#, Yue Yang#, Wenhao Xia#, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu, Kjersti Sternang Kvie, Knut H？kon R？ed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas P. Gilbert, Qiang Qiu*, Wen Wang*, Zhipeng Li*. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364 eaav6312.

　　[2] Guangqing Yu#, Xing Liu#, Jinhua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432.

　　[3] Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259.

　　[4] Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380.

　　[5] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017, 45(22): 12700-12714..

　　[6] Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749.

　　[7] Xing Liu#, Xiaolian Cai#, Bo Hu#, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.

　　[8] Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.

　　[9] Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.

　　[10] Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057.

　　[11] Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.

　　[12] Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.

　　[13] Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.

　　[14] Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.

　　[15] Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.

　　[16] Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078.

　　[17] Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30: 3397-3415.