导师队伍
| 职 称： | 副研究员 |
|---|---|
| 学 历： | 博士研究生 |
| 联系方式： | 027-68780079 |
| 电子邮件： | hanjian#ihb.ac.cn(请改#为@) |
| 办 公 室： | 3号楼729 |
| 个人网页： | http://people.ucas.edu.cn/~IHB_hanjian |
| 2003.9-2007.6 济南大学 生物技术专业 本科 2007.9-2010.6 华南师范大学 动物学专业 硕士 2011.9-2014.6 中国科学院大学/中国科学院水生生物研究所 水生生物学专业 博士 |
| 2010.7-2011.8：中国科学院水生生物研究所，环境毒理学科组，科研助理。研究方向为环境毒理学。 2014.10-2018.11：山东省科学院生物研究所，助理研究员。研究方向为基于斑马鱼模型的化合物毒性及活性评价。 2018.12-2019.12：中国科学院水生生物研究所，环境毒理学科组，助理研究员。研究方向为环境毒理学。 2019.12至今：中国科学院水生生物研究所，环境毒理学科组，副研究员。研究方向为环境毒理学。 |
| 水生生物学（硕士生） |
| 1.水环境（新）污染物的毒理学研究 基于小型鱼类模型（如斑马鱼、稀有鮈鲫等）的水环境污染物毒理学研究，特别是持久性有毒物质（PTS）、溴代阻燃剂、重金属等对水生脊椎动物的毒性效应、致毒机制等。开发基于小型鱼类等水生动物的环境毒理学评价新模型和新技术。
2.水环境（新）污染物监测与健康风险评估 基于化学分析和生物学毒性评价技术等综合策略的水环境污染物监测与环境健康风险评估，特别是针对养殖水体、河流、湖泊及饮用水源地等特定水环境开展特征污染物识别、迁移转化过程分析、污染水平检测和潜在生态健康风险评估研究。 |
| 2023.01-2026.12，国家自然科学基金，十溴二苯乙烷对斑马鱼脂质代谢的干扰效应与机制，54万元，主持。 2022.12-2027.11，国家重点研发计划“主要环境污染物对个体发育和代谢的影响及关键机制研究”项目“环境污染物干扰糖脂代谢的时空效应和分子机制研究”课题，880万元，参与。 2022.08-2024.07，国家环境保护农药环境评价与污染控制重点实验室开放课题，纳米二氧化钛对斑马鱼中TBPH富集及毒性的影响，8万元，主持。 2020.11-2025.10，国家重点研发计划，有毒金属感知修复的智能生物体系（子课题1项），48万元，主持。 2020.01-2023.12，国家自然科学基金，典型溴代阻燃剂与纳米二氧化钛、有机碳相互作用诱导的斑马鱼甲状腺内分泌干扰效应，65万元，参与。 2019.01-2021.12，国家自然科学基金，基于斑马鱼模型研究重金属镉对耳石发育的毒性效应及机制，24.5万元，主持。 2019.01-2023.12，中科院先导A专项，长江干流陆向岸线污染拦截及生态修复技术，28万元，主持。 2018.12-2022.12，国家重点研发计划（蓝色粮仓科技创新专项），典型养殖系统对自然水域生态系统的影响机理（项目），池塘养殖物质循环及对湖泊生态系统的影响机理（课题），723万元，参与。 |
| 近年来，围绕新型溴代阻燃剂、有机磷阻燃剂、环境雌激素、金属纳米材料和重金属等污染物，开展了以斑马鱼为模型的环境毒理学研究，取得了一定的科研成果。在环境领域著名期刊Environmental Science & Technology、Science of The Total Environment、Environmental Pollution、Ecotoxicology and Environmental Safety、Journal of Environmental Sciences等发表SCI论文40余篇，其中第一或通讯作者20余篇。 代表性论文（近5年）： 1. Zhou Y, Fu J, Wang M, Guo Y, Yang L, Han J, Zhou B, Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol, Journal of Environmental Sciences, 2023, 124,291-299. 2. Zhu B, Wang Z, Lei L, Guo Y, Han J, Zhou B, Transcriptome reveals overview of Ca2+ dose-dependent metabolism disorders in zebrafish larvae after Cd2+ exposure, Journal of Environmental Sciences, 2023, 125, 480-491. 3. Yan B, Han J, Sun Y, Lei L, Yuan J, Qiao Z, Men J, Wang X, Guo Y, Wang Q, Zhou B. Probiotics ameliorate growth retardation of glyphosate by regulating intestinal microbiota and metabolites in crucian carp (Carassius auratus). Sci Total Environ. 2022 Aug 25:158260. 4. Wang Q, Mao C, Lei L, Yan B, Yuan J, Guo Y, Li T, Xiong X, Cao X, Huang J, Han J, Yu K, Zhou B, Antibiotic resistance genes and their links with bacteria and environmental factors in three predominant freshwater aquaculture modes, Ecotoxicology and Environmental Safety, 2022, 241, 113832. 5. Zhu B, Lei L, Sun Y, Shi X, Fu K, Hua J, Martyniuk CJ, Han J, Yang L, Zhou B. Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish. Environ Sci Technol. 2022 Jul 28. 6. Zhu B, Lei L, Fu K, Zhao S, Hua J, Yang L, Han J, Li R, Zhou B. Neurotoxicity of tetrabromobisphenol A and SiO2 nanoparticle co-exposure in zebrafish and barrier function of the embryonic chorion. Sci Total Environ. 2022 Jul 14;845:157364. 7. Wang X, Zhao L, Shi Q, Guo Y, Hua J, Han J, Yang L. DE-71 affected the cholinergic system and locomotor activity via disrupting calcium homeostasis in zebrafish larvae. Aquat Toxicol. 2022 Jul 9;250:106237. 8. Hua J, Zhu B, Guo W, Wang X, Guo Y, Yang L, Han J, Zhou B. Endocrine disrupting effects induced by levonorgestrel linked to altered DNA methylation in rare minnow (Gobiocypris rarus). Comp Biochem Physiol C Toxicol Pharmacol. 2022 Jul;257:109332. 9. Lei L, Zhu B, Qiao K, Zhou Y, Chen X, Men J, Yang L, Wang Q, Han J, Zhou B. New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish. Sci Total Environ. 2022 May 20;822:153623. 10. Hu Z, Yang L, Han J, Liu Z, Zhao Y, Jin Y, Sheng Y, Zhu L, Hu B. Human viruses lurking in the environment activated by excessive use of COVID-19 prevention supplies. Environ Int. 2022 May;163:107192. 11. Zhou Y, Lei L, Chen P, Guo W, Guo Y, Yang L, Han J, Hu B, Zhou B. Effects of nano-TiO<sub>2</sub> on the bioavailability and toxicity of bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) in developing zebrafish. Chemosphere. 2022 May;295:133862. 12. Yan B, Lei L, Chen X, Men J, Sun Y, Guo Y, Yang L, Wang Q, Han J, Zhou B. Glyphosate and glufosinate-ammonium in aquaculture ponds and aquatic products: Occurrence and health risk assessment. Environ Pollut. 2022 Mar 1;296:118742. 13. Zhou Y, Guo W, Lei L, Sun Y, Li R, Guo Y, Yang L, Shi X, Han J, Zhou B. Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environ Pollut. 2021 Dec 1;290:118127. 14. Chen X, Lei L, Liu S, Han J, Li R, Men J, Li L, Wei L, Sheng Y, Yang L, Zhou B, Zhu L. Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China. Sci Total Environ. 2021 Oct 20;792:148352. 15. Li R, Yang L, Han J, Zou Y, Wang Y, Feng C, Zhou B. Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications. Environ Pollut. 2021 Sep 15;285:117471. 16. Guo W, Lei L, Shi X, Li R, Wang Q, Han J, Yang L, Chen L, Zhou B. Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environ Sci Technol. 2021 May 18;55(10):6926-6935. 17. Shi Q, Guo W, Shen Q, Han J, Lei L, Chen L, Yang L, Feng C, Zhou B. In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants. J Hazard Mater. 2021 May 5;409:124999. 18. Zhu B, Han J, Lei L, Hua J, Zuo Y, Zhou B. Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae. Ecotoxicol Environ Saf. 2021 Feb;209:111845. 19. Chen X, Guo W, Lei L, Guo Y, Yang L, Han J, Zhou B. Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environ Pollut. 2021 Jan 1;268(Pt B):115895. 20. Fu J, Guo Y, Wang M, Yang L, Han J, Lee JS, Zhou B. Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicol Environ Saf. 2020 Dec 15;206:111207. 21. Fu J, Guo Y, Yang L, Han J, Zhou B. Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae. Environ Res. 2020 Aug;187:109682. 22. Lei L, Qiao K, Guo Y, Han J, Zhou B. Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae. Chemosphere. 2020 Jun;249:126536. 23. Guo W, Han J, Wu S, Shi X, Wang Q, Zhou B. Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Affects Lipid Metabolism in Zebrafish Larvae via DNA Methylation Modification. Environ Sci Technol. 2020 Jan 7;54(1):355-363. 24. Li R, Guo W, Lei L, Zhang L, Liu Y, Han J, Chen L, Zhou B. Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish. Environ Int. 2020 Jan;134:105293. 25. Hu S, Han J, Yang L, Li S, Guo Y, Zhou B, Wu H. Bioconcentration, depuration and toxicity of Pb in the presence of titanium dioxide nanoparticles in zebrafish larvae. Aquat Toxicol. 2019 Sep;214:105257. 26. Han J, Liu K, Wang R, Zhang Y, Zhou B. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquat Toxicol. 2019 Sep;214:105236. 27. Wang X, Ling S, Guan K, Luo X, Chen L, Han J, Zhang W, Mai B, Zhou B. Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae. Environ Sci Technol. 2019 Jul 16;53(14):8437-8446. 28. Hu S, Han J, Yang L, Li S, Guo Y, Zhou B, Wu H. Impact of co-exposure to titanium dioxide nanoparticles and Pb on zebrafish embryos. Chemosphere. 2019 Oct;233:579-589. 29. Shi Q, Wang Z, Chen L, Fu J, Han J, Hu B, Zhou B. Optical toxicity of triphenyl phosphate in zebrafish larvae. Aquat Toxicol. 2019 May;210:139-147. 30. 《环境化学前沿（第三辑）》，2022.07，参与编著。 |
| 环境领域Aquatic Toxicology期刊编委（2023~）。
环境领域Environmental science & technology、Water research、Science of The Total Environment、Environmental pollution、Ecotoxicology and Environmental Safety、Chemosphere等期刊审稿人。 |
| 在读硕士生1名（罗丽君，2022级）；协助课题组指导在读硕士生1名，博士生3名。 |
| 欢迎具有（分子）生物学、生物化学、环境化学、环境（微）生物学、水产养殖、毒理学等学科背景的考生报考！ |