2007.9-2011.6 安徽师范大学 生物科学类专业 本科

2011.9-2013.6 武汉大学 细胞生物学专业 硕士

2013.9-2017.6 中国科学院水生生物研究所 遗传学专业 博士

2017.7-2020.12 中国科学院水生生物研究所 助理研究员

2021.1-至今 中国科学院水生生物研究所 副研究员

水产养殖（硕士生）

鱼类干扰素（IFN）系统的负调控机制、鱼类病毒免疫逃逸的分子机制

2019.1-2021.12 国家自然科学青年基金（鱼类TMEM33负调控干扰素表达的分子机制研究），24万元，主持

主要围绕鱼类Ⅰ型IFN负调控机制，分别从鱼类本身和病毒两个角度进行研究，主持国家自然科学青年基金1项，水生所青年人才项目1项，发表SCI论文21篇，其中以第一作者发表论文8篇，分别发表在Plos Pathogens、Journal of Immunology、Journal of Virology和 Frontiers in Immunology等期刊上。

代表性论文：

1. Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Jing-Yu Jiang, Dan-Dan Chen, Yong-An Zhang, Feng Xiong, Fang Zhou, Shun Li, A novel role of zebrafish TMEM33 in negative regulation of interferon production by two distinct mechanisms, Plos Pathogens, 2021, 17: e1009317.

2. Long-Feng Lu, Can Zhang, Xiao-Yu Zhou, Zhuo-Cong Li, Dan-Dan Chen, Yu-Zhou, Fang Zhou, Yong-An Zhang, and Shun Li. Zebrafish RBM47 promotes lysosome-dependent degradation of MAVS to inhibit IFN induction, Journal of Immunology, 2020, 205(7)1819-1829.

3. Long-Feng Lu, Shun Li, Zhao-Xi Wang, Shu-Bo Liu, Dan-Dan Chen, Yong-An Zhang. Zebrafish NDRG1a negatively regulates IFN induction by promoting the degradation of IRF7, Journal of Immunology, 2019, 202:119-130.

4. Long-Feng Lu, Xiao-Yu Zhou, Can Zhang, Zhuo-Cong Li, Dan-Dan Chen, Shu-Bo Liu, Shun Li. Zebrafish RPZ5 degrades the phosphorylated IRF7 to repress interferon production, Journal of Virology, 2019, 93: e01272-19.

5. Shun Li¹, Long-Feng Lu¹, Shu-Bo Liu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Yong-An Zhang. Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms, PLoS Pathogens, 2019, 15:e1007695.

6. Shun Li¹, Long-Feng Lu¹, Zhuo-Cong Li, Can Zhang, Xiao-Yu Zhou, Yu Zhou, Yong-An Zhang. Zebrafish MVP recruits and degrades TBK1 to suppress IFN production, Journal of Immunology, 2019, 202:559-566.

7. Long-Feng Lu, Zhuo-Cong Li, Can Zhang, Xiao-Yu Zhou, Yu-Zhou, Jing-Yu Jiang, Dan-Dan Chen, Shun Li, Yong-An Zhang. Grass Carp Reovirus (GCRV) giving its all to suppress IFN production by countering MAVS signaling transduction, Frontiers in Immunology, 2020, 11.

8. Long-Feng Lu, Xiao-Yu Zhou, Can Zhang, Zhuo-Cong Li, Dan-Dan Chen, Yong-An Zhang. Ca²⁺ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection, Fish & Shellfish Immunology, 2020, 102:449-459.