利用模式生物和养殖水产动物,通过基因组编辑技术,研究代谢和生长的调控机制,建立了多个脂肪分解代谢增强的水产养殖品系,提高了生长性状和饲料转化率。同时对水产动物的温度适应、肌间刺发育也有持续的研究,均产生了显著的成效。 代表性论文: (1) Enhanced insulin activity achieved in VDRa/b ablation zebrafish, FRONTIERS IN ENDOCRINOLOGY, 2023, 通讯作者 (2) Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp(Carassius gibelio), Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp (Carassius gibelio), SCIENCE CHINA-LIFE SCIENCES, 2022, 共同第一作者 (3) Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebra fish (vol 7, 88. 2016), FRONTIERS IN ENDOCRINOLOGY, 2019, 通讯作者 (4) Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio), AQUACULTURE, 2021, 通讯作者 (5) Identification of LBX2 as a novel causal gene of atrial septal defect, INTERNATIONAL JOURNAL OF CARDIOLOGY, 2018, 通讯作者 (6) Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish, REDOX BIOLOGY, 2020, 第 4 作者 (7) Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 通讯作者 (8) Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models, CELLS, 2021, 第 5 作者(9) Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish, BIOLOGY OF REPRODUCTION, 2019, 第 6 作者 (10) Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis, BIOLOGY OF REPRODUCTION, 2021, 第 8 作者(11) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3, CELL REPORTS, 2017, 第 5 作者 (12) A novel mutation in nuclear prelamin a recognition factor-like causes diffuse pulmonary arteriovenous malformations, ONCOTARGET, 2017, 第 6 作者 (13) Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos, SCIENTIFIC REPORTS, 2017, 第 2 作者 (14) Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 第 3 作者 (15) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models, SCIENTIFIC REPORTS, 2016, 第 2 作者 (16) Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish, FRONTIERS IN ENDOCRINOLOGY, 2016, 通讯作者 (17) 一种新的简单有效的斑马鱼胚胎心脏富集和提纯方法, 现代生物医学进展, 2015, 第 2 作者 (18) Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity, Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity, JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 第 6 作者 (19) Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp, ENDOCRINOLOGY, 2014, 第 2 作者 (20) Knockout Zebrafish Model for the Understanding of Prolactin Action, ENDOCRINE REVIEWS, 2014, 第 2 作者 (21) Sept6 Is Required for Ciliogenesis in Kupffer's Vesicle, the Pronephros, and the Neural Tube during Early Embryonic Development, MOLECULAR AND CELLULAR BIOLOGY, 2014, 第 4 作者 (22) Role of Zebrafish Lbx2 in Embryonic Lateral Line Development, PLOS ONE, 2011, 第 2 作者 专利: (1)一种促进鱼类生长性状改良的方法, 发明专利, 2022, 第 5 作者, 专利号: CN111454992B (2)规模化获得XX/XY性别决定的伪雄鱼亲本的育种方法及其应用, 发明专利, 2021, 第 4 作者, 专利号: CN113817779A (3)实现XX/XY性别遗传决定型鱼类性别控制育种的方法及应用, 发明专利, 2021, 第 5 作者, 专利号: CN113789352A (4)鉴别黄河鲤遗传性别的分子标记、引物、试剂盒及应用, 发明专利, 2021, 第 6 作者, 专利号: CN113774122A (5)维生素D受体激动剂用于预防和/或治疗肥胖的用途, 发明专利, 2018, 第 7 作者, 专利号: CN108853503A |