| 近年来，发现鱼类生殖质聚集和原始生殖细胞（PGC）特化需要Sinhcaf介导的组蛋白去乙酰化的调控作用，并阐明其作用机制；利用基因敲降技术构建了PGC完全剔除的鲤模型，证明鲤性别分化不依赖于PGC；以PGC完全剔除的鲤为移植受体开展黄鳝生殖干细胞移植研究，探索建立黄鳝“借腹生殖”新技术；合作揭示神经内分泌因子SN在斑马鱼胚胎发育及生殖与性行为中的新功能，发现斑马鱼GnRH3神经元通过直接感知和传递性信息素，诱发生殖行为；发现神经营养因子Gdnfa在斑马鱼精巢发育中发挥重要功能。 代表性论文：#共同第一作者，*通讯作者 1. Tao, B.B#, Hu, H.L#, Chen, J., Chen, L., Luo, D.J., Sun, Y.H., Ge, F., Zhu, Z.Y., Trudeau, V.L., and Hu, W*, Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. Embo Reports, 2022, 23(6): p. e54387. 2. Tao, B.B., Hu, H.L., Mitchell, K., Chen, J., Jia, H.B., Zhu, Z.Y., Trudeau, V.L., Hu, W. Secretogranin-II plays a critical role in zebrafish neurovascular modeling. J Mol Cell Biol, 2018, 10(5), 388-401. 3. Tao, B.B, Tan, J., Chen, L., Xu, Y., Liao, X., Li, Y., Chen, J., Song, Y., and Hu, W., CRISPR/Cas9 system-based myostatin-targeted disruption promotes somatic growth and adipogenesis in loach, Misgurnus anguillicaudatus. Aquaculture, 2021, 544: p. 737097. 4. Tao, B.B, Liao, X.Y, Chen, L., Li, Y., Chen, K., Jia, S., Wu, X., Ma, W., Wu, Y., Zhong, W., Chen, J., Song, Y., and Hu, W., Germ cells are not essential for sexual dimorphism of gonads in common carp, C. carpio L. Aquaculture, 2022,547: p. 737501. 5. Liao, X.Y., Tao, B.B*., Zhang, X.Y., Chen, L., Chen, J., Song, Y.L., and Hu, W., Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology, 2023, 576: p. 112010. 6. Tao, B.B#, Chen, K.X#, Zhang, X.Y, Liao, X.Y, Luo, H.R, Song, Y.L, Chen, J., Zhou, W.Z, Hu, W. Establishment of inter-order transplantation of primordial germ cells for the protogynous hermaphroditic rice field eel, Monopterus albus. Water Biology and Security, 2025, 100446. 7. Chen, K. X., Rong, Y., Guo, Y. Q., Jiang, M. Y., Wei, Y. L., Shan, X. S., Li, Y. M., Song, Y. L., Chen, J., Tao, B. B*. and Hu, W*. Active spermatogenesis in YY supermale common carp makes it suitable for potential control of this invasive species. Aquaculture, 2025, 603, 742396. 8. Cui, X.F.#, Chen, L.#, Tao, B.B.#, Zhang, X.Y., Song, Y.L., Chen, J., Duan, M., Li, W.W., Chen, K.X., Pei, Y., Hu, X.R., Feng, K., Luo, D.J., Luo, H.R., Qiao, Z.X., Zhou, F., Zhu, Z.Y. *, Trudeau, V.L*., Hu, W*. Olfactory GnRH3 crypt sensory neurons transduce sex pheromone signals to induce male courtship behavior in zebrafish. Sci. China. Life. Sci. 2025, https://doi.org/10.1007/s11427-025-2917-5. 9. Hou, M.X., Feng, K., Luo, H.R., Jiang, Y.J., Xu, W., Li, Y.M., Song, Y.L., Chen, J., Tao, B.B*., Zhu, Z.Y., and Hu, W*., Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish. Marine Biotechnology, 2022, 24(2): p. 320-334. 10. Mitchell, K., Zhang, W.S., Lu, C.Y., Tao, B.B., Chen, L., Hu, W. *, Trudeau, V.L.* Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. PNAS. 2020, 117, 12772-12783. 授权专利： 1. 陶彬彬，张西娅，宋焱龙，罗红瑞，陈戟，胡炜，一种黄鳝生殖细胞异种移植及移植后嵌合性腺的检测方法。中国发明专利，2023年9月15日授权，专利号ZL 202210411188.3 2. Hu Wei, Jiang Mouyan, Li Yongming, Tao Binbin, Chenji and Zhu Zuoyan. Method for production YY super-male and XY physiological female common carps. 2020年获美国发明专利，专利号：US 10701907 B2。 3. 宋焱龙，蒋银军，陶彬彬，陈戟，罗红瑞，朱作言，胡炜。一种人工诱导黄鳝直接定向发育为雄性的培育方法。中国发明专利， 2023年1月18日授权，专利号ZL202210017492.X 4. 宋焱龙，蒋银军，罗红瑞，陶彬彬，陈戟，罗大极，胡炜。基于黄鳝促性腺激素释放激素类似物的黄鳝人工催产方法。中国发明专利， 2023年5月26日授权，专利号ZL202210280223.2 |
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