专家简介：

    女，博士，中国科学院水生生物所二级研究员，博士生导师，鱼类生物学及渔业生物技术研究中心主任，所学位委员会副主任。《水生生物学报》、《微生物学报》和《微生物学通报》编委;国际病毒分类委员会委员;湖北省微生物学会和湖北省电镜学会理事;农业部水产养殖病害防治专家委员会委员。

在武汉大学病毒学系获理学学士学位;在美国俄亥俄医学院获生物医学硕士学位;在中国科学院水生生物研究所获理学博士学位。先后在中国科学院武汉病毒研究所、美国俄亥俄医学院、美国加州大学圣迭戈分校 (University of California，San Diego) 和中国科学院水生生物研究所从事病毒学及分子生物学相关领域的研究工作。发表论文近170篇，其中SCI论文74篇;主(著)编论著2部，参编论著8部。获湖北省自然科学二等奖、中国科学院优秀研究生导师奖、中国科学院教学成果二等奖、中国科学院朱李月华优秀教师奖、湖北省优秀博士学位论文指导教师奖(2项);获国家授权发明专利6项。已培养毕业博士17位，硕士5位，出站博士后2位。在毕业博士中，获中国科学院院长奖1位，湖北省优秀博士论文奖2位，中科院“地奥”奖学金 3位，研究生国家奖学金 2人/次，三好学生标和优秀毕业生奖6位。

    主持的学科组长期从事水生病毒学及其分子生物学研究。重点关注：水生病毒学、水生动物免疫与疫苗，水生病毒分子生物学、噬藻体与淡水浮游病毒等基础理论与应用技术的研究。

研究方向：水生病毒学及其分子生物学

专家类别：享受政府特殊津贴

获奖及荣誉：

    湖北省自然科学二等奖(2004)

    中国科学院教学成果二等奖(2008)，

    获中国科学院朱李月华优秀教师奖(2009)，

    湖北省优秀博士学位论文指导教师奖(2009，2012)。

Representative Publications：

　　LB, Ke F, Wang J, Gao XC, Zhang QY. 2014. Rana grylio virus (RGV) envelope protein 2L subcellular localization and essential roles in virus infectivity revealed by conditional lethal mutant. J Gen Virol 95:679-690

　　Zhu R, Chen ZY, Wang J, Yuan JD, Liao XY, Gui JF, Zhang QY. 2014. Extensive diversification of MHC in Chinese giant salamanders Andrias davidianus (Anda-MHC) reveals novel splice variants. Dev & Comp Immunol, 42:311-322

　　Ke F, He LB, Zhang QY, 2013. Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. Plos One, 8(5): e63737

　　Zhu R, Wang J, Lei XY, Gui JF, Zhang QY. 2013. Evidence for Paralichthys olivaceus IFITM1 antiviral effect by impeding viral entry into target cells. Fish Shellfish Immunol. 35:918-926

　　He LB, Gao XC, Ke F, Zhang QY. 2013. A conditional lethal mutation in Rana grylio virus ORF 53R resulted in a marked reduction in virion formation. Virus Res. 177:194-200

　　Ou T, Zhu RL, Chen ZY, Zhang QY. 2013. Isolation and identification of a lethal rhabdovirus from farmed rice field eels Monopterus albus. Dis Aquat Org, 106:197-206

　　Chen ZY, Gui JF, Gao XC, Pei C, Hong YJ, Zhang QY. 2013. Genome architecture changes and major gene variations of Andrias davidianus ranavirus (ADRV). Veterinary Research, 44:101

　　Lei XY, Tong Ou, Qi-Ya Zhang. Rana grylio virus (RGV) 50L is associated with viral matrix and exhibited two distribution patterns. Plos One, 2012, 7(8): e43033

　　Gao EB, Gui JF, Zhang QY. 2012. A novel cyanophage with cyanobacterial non-bleaching protein a gene in the genome. Journal of Virology, 86(1):236-245

　　Li S, Sun F, Zhang YB, Gui JF, Zhang QY. 2012. Identification of Zebrafish Gig2 as a Novel Antiviral Factor Regulated by RLR Signaling Pathway. Plos One, 7(3): e32427

　　He LB, Ke F, Zhang QY. 2012. Rana grylio virus as a vector for foreign gene expression in fish cell. Virus Research, 163: 66-73

　　Chen ZY, Lei XY, Zhang QY. 2012. The antiviral defense mechanisms in mandarin fish induced by DNA vaccine against a rhabdovirus. Veterinary Microbiology, 157: 264-275

　　Pei C, Lei XY, Yuan XP, Wang D, Zhao QZ, Zhang QY. 2012. Herpes-like virus infection in Yangtze finless porpoise (Neophocaena phocaenoides): pathology, ultrastructure and molecular analysis, Journal of Wildlife Diseases, 48 (1): 235-237

　　Lei XY, Chen ZY, He LB, Pei C, Yuan XP, Zhang QY. 2012. Characterization and virus susceptibility of a skin cell line from red-spotted grouper (Epinephelus akaara). Fish Physiol Biochem, (in press)

　　Lei XY, Ou T, Zhu RL, Zhang QY. 2012. Sequencing and analysis of the complete genome of Rana grylio virus (RGV). Archives of Virology, 157:1559–1564

　　Jancovich JK, Chinchar VG, Hyatt A, Miyazaki T, Williams T, Zhang QY. 2011. Family Iridoviridae. In: King AMQ, et al (eds). Virus Taxonomy, 9th Report of the ICTV. Elsevier/Academic Press, pp196-210

　　Ke F, He LB, Pei C, Zhang QY. 2011. Turbot reovirus (SMReV) genome encoding a FAST protein with a non-AUG start site. BMC Genomics,12:323

　　Zhu RL, Lei XY, Ke F, Yuan XP, Zhang QY. 2011. Genome of turbot rhabdovirus exhibits unusual non-coding regions and a novel additional ORF that could be expressed in fish cell. Virus Research 155: 495-505

　　Kim YS, Ke F, Lei XY, Zhu R, Zhang QY. 2010. Viral envelope protein 53R gene highly specific silencing and iridovirus resistance in fish cells by amiRNA. PLoS One, 5(4):e10308

　　Zhao Z, Ke F, Shi Y, Zhou GZ, Gui JF, Zhang QY, 2009. Rana grylio virus thymidine kinase gene: an arly gene of iridovirus encoding for the cytoplasmic protein. Virus Gene, 38:345–352

　　Kim YS, Ke F, Zhang QY, 2009. Effect of β-glucan on activity of antioxidant enzymes and Mx gene expression in virus infected grass carp. Fish & Shellfish Immunology,27:336-340

　　Gao EB, Yuan XP, Li RH, Zhang QY, 2009. Isolation of a novel cyanophage infectious to filamentous cyanobacterium Planktothrix agardhii (cyanophyceae) from Lake Donghu in China. Aquatic Microbial Ecology, 54:153-162

　　Ke F, Zhao Z, Zhang QY. 2009. Cloning, expression and subcellular distribution of a Rana grylio virus late gene encoding ERV1 homologue. Molecular Biology Reports, 36:1651–1659

　　Zhao Z, Ke F, Huang YH, Zhao JG, Gui JF, Zhang QY, 2008. Identification and haracterization of a novel envelope protein in Rana grylio virus. Journal of General Virology, 89: 1866-1872

　　Zhu R, Zhang YB, Zhang QY, Gui JF, 2008. Functional domains and the antiviral effect of the dsRNA-dependent protein kinase PKR from Paralichthys olivaceus. Journal of Virology, 82: 6889-6901

　　Zhao Z, Shi Y, Ke F, Wei W, Gui JF, Zhang QY, 2008. Constitutive expression of thymidylate synthase from LCDV-C induces foci formation and anchorage-independent growth in fish cells. Virology, 372:118-126

　　Tao JJ, Zhou GZ, Gui JF, Zhang QY, 2008. Genomic sequence of mandarin fish rhabdovirus with an unusual small non-transcriptional ORF. Virus Research, 132:86–96

　　Zhou GZ, Gui L, Li ZQ, Yuan XP, Zhang QY, 2008. Generation and characterization of monoclonal antibodies against the flounder Paralichthys olivaceus rhabdovirus. Journal of virological Methods. 148: 205–210

　　Zhao Z, Ke F, Li ZQ, Gui JF, Zhang QY, 2008.Isolation, characterization and genome sequence of a birnavirus strain from flounder Paralichthys olivaceus in China. Archives Virology, 153:1143–1148

　　Chen ZY, Liu H, Li ZQ, Zhang QY, 2008. Development and characterization of monoclonal antibodies to spring viraemia of carp virus. Veterinary Immunology and Immunopathology, 123:266-276

　　Lü AJ, Li ZQ, Zhang QY, 2008. Detection of cutaneous antibodies in excised skin explants from Grass carp, Ctenopharyngodon idellus, immune to Scophthalmus maximus rhabdovirus. Journal of Fish Diseases,31:559-565

　　Huang YH, Huang XH, Gui JF, Zhang QY, 2007.Mitochondria-mediated apoptosis induced by Rana glylio virus infection in fish cells. Apoptosis, 12(9):1569-1577

　　Zhao Z, Ke F, Gui JF, Zhang QY, 2007. Characterization of an early gene encoding for dUTPase from Rana grylio virus. Virus Research, 123:128–137

　　Tao JJ, Zhang QY, Gui JF, 2007. Isolation and characterization of a rhabdovirus from coinfection of two viruses in mandarin fish. Aquaculture, 262(1):1-9

　　Huang YH, Huang XH, Zhang J, Gui JF, Zhang QY，2007. Subcellular localization and characterization of G protein-coupled receptor homolog from lymphocysis disease virus isolated in China. Viral Immunology, 20(1): 150-159

　　Zhou GZ, Li ZQ, Zhang QY,2007.Establishment, characterization and virus susceptibility of a new marine cell line from red spotted grouper (Epinephelus akaara). Marine Biotechnology, 9 (3): 370-376

　　Zhang QY, Tao JJ, Gui L, Zhou GZ, Ruan HM, Li ZQ, Gui JF, 2007. Isolation and characterization of Scophthalmus maximus (turbot) rhabdovirus. Diseases of Aquatic Organisms. 74:95-105

　　Huang XH, Zhang QY, 2007. Improvement and observation of immunoelectron microscopic method for the localization of frog Rana grylio virus (RGV) in infected fish cells. Micron, 38(6):599-606

　　Lü AJ, Dong CW, Du CS, Zhang QY, 2007. Characterization and inductive expression of flounder voltage-dependent anion channel gene (VDAC) in response to virus infection. Fish & Shellfish Immunology, 23:601-613

　　Huang XH, Huang YH, Yuan XP, Zhang QY, 2006. Electron microscopic Analysis of the Viromatrix of Rana grylio Virus in a Fish Cell line. Journal of Virological Methods, 133(2):117-123

　　Zhang QY, Zhao Z, Xiao F, Li ZQ, Gui JF, 2006. Molecular characterization of three Rana grylio virus (RGV) isolates and Paralichthys olivaceus lymphocystis disease virus (LCDV-C) in iridoviruses. Aquaculture, 251: 1-10

　　Liu YM, Zhang QY, Yuan XP, Li ZQ, Gui JF, 2006. Seasonal variation of virioplankton in a eutrophic shallow lake. Hydrobiologia, 560:323-334

　　Zhu R, Zhang YB, Chen YD, Dong CW, Zhang FT, Zhang QY, Gui JF, 2006. Molecular cloning and stress-induced expression of paralichthys olivaceus heme-regulated initiation factor 2alpha kinase. Developmental & Comparative Immunology, 30(11):1047-1059

　　Liu YM, Yuan XP, Zhang QY, 2006. Spatial distribution and morphologic diversity of virioplankton in Lake Donghu, China. Acta Oecologica-International Journal of Ecology, 29: 328-334

　　Sun W, Huang YH, Zhao Z, Gui JF, Zhang QY, 2006. Characterization of the Rana grylio virus 3β-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect. Biochemical & Biophysical Research Communications, 351:44–50

　　Zhou GZ, Li ZQ, Zhang QY, 2006. Characterization and application of monoclonal antibodies against the turbot (Scophthalmus Maximus) rhabdovirus (SMRV). Viral Immunology, 19(4):637-645

　　Du CS, Zhang QY, Li CL, Miao DL, Gui JF. 2004. Induction of apoptosis in a carp leucocyte cell line infected with turbot (Scophthalmus maximus L.) rhabdovirus. Virus Research, 101: 119-126

　　Zhang QY, Xiao F, Xie J, Li ZQ, Gui JF. 2004. Complete genome sequence of lymphocystis disease virus (LCDV-C) isolated from China. Journal of Virology, 78(13): 6982-6994

　　张奇亚，桂建芳 著，水生病毒与病毒病图鉴，科学出版社，北京，2012年 pp1-479 [Zhang QY, Gui JF. 2012. Atlas of Aquatic Viruses and Viral Diseases. Science Press, Beijing, pp1-479]

　　张奇亚，桂建芳主编, 水生病毒学, 中国高等教育出版社, 北京, 2008年1月出版 pp1-414 [Zhang QY, Gui JF. 2008. Aquatic Virology, Higher Education Press, Beijing, pp1-414]