个人简历：

　　博士，研究员，博士生导师。2001年毕业于华中农业大学获硕士学位;2005年毕业于中国科学院水生生物研究所获博士学位;2008~2010年，在英国阿伯丁大学进行访问研究或合作研究;2015年鱼类比较免疫学学科组学科带头人。主要致力于病原与宿主相互作用的分子机理、病原感染的免疫应答机制、病原清除机制以及渔用疫苗研制方面的研究。近年来，主持了国家自然科学基金重点项目、面上项目、青年科学基金、以及中科院方向性项目子课题，参与了“973”课题、中国科学院战略性先导科技专项“分子模块设计育种创新体系”子课题等研究工作。在PLOS Pathogens、Frontiers in Immunology、Journal of Virology、Immunology、Veterinary research、Developmental and comparative immunology等国际著名学术期刊上发表SCI论文70余篇，引用1000余次。

　　研究方向：

　　感染免疫学，病原微生物学，比较免疫学

　　招生专业：水生生物学

　　电话: 　86-27-68780760

    电子邮件: 　mingxianchang#ihb.ac.cn(发邮件时将#换成@)

　　期刊论文(*通讯作者)：

　　1. Cao L, Wu XM, Nie P, Chang MX*. The negative regulation of piscine CD44c in viral and bacterial infection. Dev Comp Immunol. 2019 Jul;96:135-143.

　　2. Rahman K, Khan SU, Fahad S*, Chang MX*, Abbas A, Khan WU, Rahman L, Haq ZU, Nabi G, Khan D. Nano-biotechnology: a new approach to treat and prevent malaria. Int J Nanomedicine. 2019 Feb 21;14:1401-1410.

　　3. Zhang J, Guo H, Zhang F, Chen Q, Chang M*, Fang Q*. NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. Virology. 2019 Feb 1;529:216-225.

　　4. Wu XM, Chen WQ, Hu YW, Cao L, Nie P, Chang MX*. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Front Immunol. 2018 Apr 10;9:726.

　　5. Cao L, Wu XM, Hu YW, Xue NN, Nie P, Chang MX*. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Dev Comp Immunol. 2018 Jul;84:153-163.

　　6. Hu YW, Zhang J, Wu XM, Cao L, Nie P, Chang MX*. TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Front Immunol. 2018 Jan 30;9:84.

　　7. Zhen X, Zhou H, Ding W, Zhou B, Xu X, Per？ulija V, Chen CJ, Chang MX, Choudhary MI, Ouyang S*. Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages. Protein Cell. 2018 Nov 12.

　　8. Zhang B, Ye W, Ye Y, Zhou H, Saeed AFUH, Chen J, Lin J, Per？ulija V, Chen Q, Chen CJ, Chang MX, Choudhary MI, Ouyang S*. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. Cell Res. 2018 Dec;28(12):1198-1201.

　　9. 任诗思，齐志涛，昌鸣先*. 大鲵短型肽聚糖识别蛋白PGRP-S的克隆及其功能研究.水生生物学报, 2018,42(3):473-479.

　　10. Chang MX*, Zhang J. Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection. Int J Mol Sci. 2017 Jul 15;18(7).

　　11. Hu YW, Wu XM, Ren SS, Cao L, Nie P, Chang MX*. NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Sci Rep. 2017 Jun 7;7(1):2979.

　　12. Wu XM, Hu YW, Xue NN, Ren SS, Chen SN, Nie P, Chang MX*. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Dev Comp Immunol. 2017 Mar;68:58-68.

　　13. Zhang L, Chen WQ, Hu YW, Wu XM, Nie P, Chang MX*. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016 Jul;54:135-43.

　　14. Fan Y, Chang MX, Ma J, LaPatra SE, Hu YW, Huang L, Nie P*, Zeng L*. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus. Vet Res. 2015 Nov 20;46:136.

　　15. Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX*. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015 Mar;49(1):19-30.

　　16. Yu ZL, Li JH, Xue NN, Nie P, Chang MX*. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014 Dec;47(2):264-74.

　　17. Hu YW, Yu ZL, Xue NN, Nie P, Chang MX*. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Dev Comp Immunol. 2014 Oct;46(2):323-32.

　　18. Chang MX, Zou J, Nie P, Huang B, Yu Z, Collet B, Secombes CJ*. Intracellular interferons in fish: a unique means to combat viral infection. PLoS Pathog. 2013;9(11):e1003736.

　　19. Zou PF, Chang MX*, Xue NN, Liu XQ, Li JH, Fu JP, Chen SN, Nie P*. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014 Feb;141(2):192-202.

　　20. Li JH, Yu ZL, Xue NN, Zou PF, Hu JY, Nie P, Chang MX*. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014 Feb;42(2):244-55.

　　21. Wang G, Li J, Zou P, Xie H, Huang B, Nie P, Chang M*. Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2012 Sep;33(3):522-31.

　　22. Chang M, Collet B, Nie P*, Lester K, Campbell S, Secombes CJ, Zou J*. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss). J Virol. 2011 Aug;85(16):8403-12.

　　23. Guo HZ, Zou PF, Fu JP, Guo Z, Zhu BK, Nie P, Chang MX*. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol. 2011 Feb;30(2):515-24.

　　24. Chang M, Wang T, Nie P, Zou J, Secombes CJ*. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol. 2011 Jan;30(1):118-27.

　　25. Chang MX, Chen WQ, Nie P*. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Dev Comp Immunol. 2010 Jan;34(1):1-13.

　　26. Chang M, Nie P, Collet B, Secombes CJ, Zou J*. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics. 2009 Apr;61(4):315-25.

　　27. Chang MX, Wang YP, Nie P*. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish Shellfish Immunol. 2009 Feb;26(2):264-74.

　　28. Chang MX, Nie P*. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008 Aug 15;124(3-4):295-301.

　　29. Chang MX, Nie P*, Wei LL. Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Mol Immunol. 2007 Apr;44(11):3005-23.

　　30. Chang MX, Nie P*. Intelectin gene from the grass carp Ctenopharyngodon idella: cDNA cloning, tissue expression, and immunohistochemical localization. Fish Shellfish Immunol. 2007 Jul;23(1):128-40.

　　31. Chang MX, Sun BJ, Nie P*. The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Mol Immunol. 2007 Feb;44(6):1123-34.

　　32. Chang MX, Nie P*, Xie HX, Wang GL, Gao Y. Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella. Vet Immunol Immunopathol. 2006 Mar 15;110(1-2):51-63.

　　33. Chang MX, Nie P*, Liu GY, Song Y, Gao Q. Identification of immune genes in grass carp Ctenopharyngodon idella in response to infection of the parasitic copepod Sinergasilus major. Parasitol Res. 2005 Jun;96(4):224-9.

　　34. Chang MX, Nie P*, Sun BJ, Yao WJ. Molecular cloning of TRAF2 binding protein gene and its promoter region from the grass carp Ctenopharyngodon idellus. Vet Immunol Immunopathol. 2005 May 1;105(1-2):105-13.

　　35. Chang MX, Nie P*, Xie HX, Sun BJ, Gao Q. Characterization of two genes encoding leucine-rich repeat-containing proteins in grass carp Ctenopharyngodon idellus. Immunogenetics. 2005 Jan;56(10):710-21.