男，1987 年4月生，中共党员，博士，副研究员，硕士生导师。研究领域为鱼类抗病育种、鱼类功能基因发掘、病毒致病机制、病毒-宿主相互作用等。现主持国家自然科学基金青年基金、湖北省自然科学基金、中科院水生所青年人才领域前沿项目、国家重点实验室开放课题等项目，参与国家自然科学基金、中科院战略先导专项等多个项目。以第一作者/通讯作者身份在Oncotarget、BMC Genomics、Fish & Shellfish Immunology等杂志发表SCI论文14篇。

2004-2008年，中国地质大学(武汉)，环境学院，理学学士;

2008-2013年，中国科学院水生生物研究所，理学博士(硕博连读);

2013-2017年，中国科学院水生生物研究所，助理研究员;

2017年-至今，中国科学院水生生物研究所，副研究员。

招生专业：遗传学

招生方向：鱼类抗病育种、鱼类功能基因发掘、病毒致病机制、病毒-宿主相互作用

联系电话：027-68780119

电子邮箱：helibowudi#ihb.ac.cn(发邮件时将#换成@)

代表论文：

1. He LB, Xiong L, Zhang AD, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Changes in gene and genotype frequencies during the development of the grass carp Ctenopharyngodon idella. J Fish Biol. 2018, 93(6): 1113-1120.

2. Chu PF1#, He LB1#, Xiong L, Luo LF, Huang R, Liao LJ, Li YM, Zhu ZY, Wang YP. Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2018, 76: 316-323. (#co-first author)

3. Xiong L, He LB*, Luo LF, Li YM, Liao LJ, Huang R, Zhu ZY, Wang YP*. Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection. Int J Mol Sci. 2018, 19(4): E1110. (*co-corresponding author)

4. He LB, Wang H, Luo LF, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis. Oncotarget. 2017, 8(44): 76408-76422.

5. He LB, Zhang AD, Xiong L, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection. Int J Mol Sci. 2017, 18(9): E1977.

6. He LB, Zhang AD, Pei YY, Chu PF, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Differences in responses of grass carp to different types of grass carp reovirus (GCRV) and the mechanism of hemorrhage revealed by transcriptome sequencing. BMC genomics. 2017, 18: 452.

7. He LB, Zhang AD, Chu PF, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection. BMC Genomics, 2017, 18: 195.

8. He LB, Wang H, Luo LF, Jiang SH, Liu LY, Li YM, Huang R, Liao LJ, Zhu ZY, Wang YP. Characterization, expression analysis and localization pattern of toll-like receptor 1(tlr1) and toll-like receptor 2 (tlr2) genes in grass carp Ctenopharyngodon idella. J Fish Biol. 2016, 89(2):1434-40.

9. He LB, Pei YY, Jiang Y, Li YM, Liao LJ, Zhu ZY, Wang YP. Global gene expression patterns of grass carp following compensatory growth. BMC genomics, 2015, 16: 184.

10. Jiang Y1#, He LB1#, Ju CS, Pei Y,Y Ji MH, Li YM, Liao LJ, Jang SH, Zhu ZY, Wang YP. Isolation and expression of grass carp toll-like receptor 5a (CiTLR5a) and 5b (CiTLR5b) gene involved in the response to flagellin stimulation and grass carp reovirus infection. Fish Shellfish Immunol, 2015, 44(1): 88-99. (#co-first author)

11. He LB, Ke F, Wan J, Gao XC, Zhang QY. Rana grylio virus (RGV) envelope protein 2L：subcellular localization and essential roles in virus infectivity revealed by conditional lethal mutant. J Gen Virol, 2014, 95: 679-690.

12. He LB, Gao X C, Ke F, Zhang QY. A conditional lethal mutation in Rana grylio virus ORF 53R resulted in a marked reduction in virion formation. Virus Res, 2013, 177:194-200.

13. Ke F1#, He LB1#, Zhang QY. Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. Plos One, 2013, 8(5): e63737. (#co-first author).

14. He LB, Ke F, Zhang QY. Rana grylio virus as a vector for foreign gene expression in fish cells. Virus Res, 2012, 163 (1): 66-73.