翟刚

　　个人简介：

　　男，1986年生，中共党员，博士，中国科学院青年创新促进会会员，副研究员，硕士生导师。

　　2010年9月至2014年12月，中国科学院水生生物研究所，理学博士

　　2015年3月至2018年12月，中国科学院水生生物研究所，助理研究员

　　2019年1月-至今，中国科学院水生生物研究所，副研究员

　　主持国家自然科学基金-面上项目、国家自然科学基金-青年基金、水生所青年人才专项和中科院青促会人才项目。同时，参与了国家自然科学基金-重点项目、国家重点研发计划-蓝色粮仓科技创新专项等多项课题。已在Engineering、Endocrinology、Science Bulletin、American Journal of Physiology-Endocrinology and Metabolism、Molecular and Cellular Biology等SCI刊物发表论文10余篇。

　　研究领域：鱼类遗传学。主要从事鲤科模式鱼类-斑马鱼和鲤科养殖鱼类-鲤的性腺发育和性别分化的机制研究。通过在斑马鱼中阻断性类固醇激素的合成，构建了雄激素和雌激素缺乏的模型，发现了鱼类中存在垂体Fshβ通路在精巢发育/精子发生中的反馈补偿机制、雌激素对卵巢发育的可塑机制和雄激素对雄性第二性征的维持机制等。将阻断性类固醇激素合成的策略在两性异形的鲤中进行应用，首创了可大规模连续生产的全雌鲤和高伪雄鲤群体，显著提升了养殖产量和效率。

　　招生专业：遗传学

　　招生方向: 鱼类遗传学

　　联系电话: 027-68780082

　　电子邮件：zhaigang#ihb.ac.cn(发邮件时将#换成@)

　　代表文章：

　　1. Zhai G, Shu T, Chen K, Lou Q, Jia J, Huang J, Shi C, Jin X, He J, Jiang D, Qian X, Hu W, Yin Z. 2021. Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carps. Engineering In press.

　　2. Zhai G, Gu Q, He J, Lou Q, Chen X, Jin X, Bi E, Yin Z. 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. Molecular and Cellular Biology 34(7), 1310-1321.

　　3. Zhai G, Shu T, Xia Y, Lu Y, Shang G, Jin X, He J, Nie P, Yin Z. 2018 Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. Endocrinology 159(10):3549-62.

　　4. Zhai G, Song J, Shu T, Yan J, Jin X, He J, Yin Z. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics 44 (6): 307-317.

　　5. Yang B1, Zhai G1, Gong Y1, Su J, Peng X, Shang G, Han D, Jin J, Liu H, Du Z, Yin Z., Xie S. 2018. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American Journal of Physiology - Endocrinology and metabolism 315, E38-E51.

　　6. Zhai G1, Shu T1, Xia Y, Jin X, He J, Yin Z. 2017. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Science Bulletin 62 (3):197-203.

　　7. Yang B1, Zhai G1, Gong Y, Su J, Han D, Yin Z, Xie S. 2017. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science Bulletin 62 (7):486-492.

　　8. Gong Y1, Zhai G1, Su J, Yang B, Jin J, Liu H, Yin Z, Xie S, Han D. 2018. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. General and Comparative Endocrinology 269:33-45.

　　9. Shu T, Shu Y, Gao Y, Jin X, He J, Zhai G#, Yin Z#. 2018. Depletion of tissue-specific ion transporters causes differential expression of PRL targets in response to increased levels of endogenous PRL. Frontiers in Endocrinology 9, 683.

　　10. Peng X, Shang G, Wang W, Chen X, Lou Q, Zhai G, Li D, Du Z, Ye Y, Jin X, He J, Zhang Y, Yin Z. 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1alpha,25(OH)2D3. Cell Reports 19, 1444-1455.

　　11. Li D, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z. 2014. Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp. Endocrinology 155 (6):2199-2212.

　　12. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q, Yin Z. 2016. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in Endocrinology 7, 88.

　　13. Yang J, Li Z, Gan X, Zhai G, Gao J, Xiong C, Qiu X, Wang X, Yin Z, Zheng, F. 2016. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences 17 (11): 1746.

　　14. Dai X, Shu Y, Lou Q, Tian Q, Zhai G, Song J, Lu S, Yu H, He J, Yin Z. 2017. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish. International Journal of Molecular Sciences 18 (6), 1127.

　　15. Shi C, Lu Y, Zhai G, Huang J, Shang G, Lou Q, Li D, Jin X, He J, Du Z, Gui J, Yin Z. 2019. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of Molecular Cell Biology 18;12(4):291-304.

　　16. Shang G, Peng X, Ji C, Zhai G, Ruan Y, Lou Q, Jin X, He J, Wang H, Yin Z. 2019. Star and LH are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of Reproduction 101(4):760-770.

　　17. Luo J, Zhang X, He S, Lou Q, Zhai G, Shi C, Yin Z, Zheng F, 2020. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology 28, 101355.

　　18. Shu T, Zhai G, Pradhan A, Olsson PE, Yin Z, 2020. Zebrafish cyp17a1 Knockout Reveals that Androgen-Mediated Signaling is Important for Male

　　Brain Sex Differentiation. General and Comparative Endocrinology 295:113490.