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熊倩    

个人简介:

女,1984 年生,中共党员,博士,副研究员,硕士生导师。多年来从事蛋白质组学和非编码RNA功能研究工作。近年来在Molecular and Cellular Proteomics, Journal of Proteome Research等国际专业杂志发表多篇通讯作者或第一作者论文。作为课题负责人承担有国家自然科学基金,国家重点实验室开放基金,中国科学院知识创新工程青年人才领域前沿项目等多个基金项目。

2002-2006年,湖北大学,生命科学学院,理学学士

2006-2011年,中国科学院水生生物研究所,理学博士

2011-2017年,中国科学院水生生物研究所,助理研究员

2017年-至今,中国科学院水生生物研究所,副研究员

近期研究兴趣:1)蓝藻内非编码RNA的生物系统发现和生物学功能;2)非编码RNA相互作用蛋白的大规模鉴定和功能研究;3)定量蛋白质组学在水生生物领域的应用

招生专业:遗传学

招生方向:非编码RNA-蛋白相互作用及其功能研究,功能蛋白质组学

联系电话:027-68780730

电子邮箱:xiongqian#ihb.ac.cn(发邮件时将#换成@)

代表论文(*通讯作者,#第一作者):

1. Wu Y#, Xiong Q#, Li ST, Yang X, Ge F, Integrated proteomic and transcriptomic analysis reveals long noncoding RNA HOTAIR promotes hepatocellular carcinoma cell proliferation by regulating opioid growth factor receptor (OGFr). Molecular & Cellular Proteomics 2018; 17(1):146-159.

2. Wu Y, Lou QY, Ge F, Xiong Q*. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports 2017; 7(1): 4022.

3. Yang X#, Xiong Q#, Wu Y, Li S, Ge F, Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells, Journal of Proteome Research 2017; 16(10): 3891-3902.

4. Zhang H, Yang L, Ling J, Czajkowsky DM, Wang JF, Zhang XW, Zhou YM, Ge F, Yang M, Xiong Q, Guo SJ, Le HY, Wu SF, Yan W, Liu B, Zhu H, Chen Z, Tao S. Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic, PNAS 2015; 112 (49): 15084-15089.

5. Xiong Q, Feng J, Li ST, Zhang GY, Qiao ZX, Chen Z, Wu Y, Lin Y, Li T, Ge F, Zhao JD. Integrated Transcriptomic and Proteomic Analysis of the Global Response of Synechococcus to High Light Stress. Molecular&Cellular Proteomics 2015; 14(4):1038-53.

6. Zheng P#, Xiong Q#, Wu Y, Chen Y, Chen Z, Fleming J, Gao D, Bi LJ, Ge F. Quantitative proteomics analysis reveals novel insights into mechanisms of action of long noncoding RNA HOTAIR in HeLa cells. Molecular&Cellular Proteomics 2015; 14(6):1447-63.

7. Xiong Q, Chen Z, Ge F. Proteomic analysis of post translational modifications in cyanobacteria. Journal of Proteomics 2016; 134: 57-64.

8. Muhseen ZT#, Xiong Q#, Chen Z, Ge F. Proteomics studies on stress responses in diatoms. Proteomics 2015; 15(23-24): 3943-53

9. Yang M, Yang Y, Zhang J, Chen Z, Lin Y, Wang Y, Xiong Q, Li T, Ge F and Zhao JD. Genome annotation and global analysis of post-translational modifications in prokaryotes. PNAS 2014; 111(52):E5633-42.

10. Tian M#, Chen X#, Xiong Q#, Xiong J, Xiao C, Ge F, Yang F, Miao W. Phosphoproteomic analysis of protein phosphorylation networks in Tetrahymena thermophila, a Model Single-Celled Organism. Molecular&Cellular Proteomics 2014; 13(2):503-19

11. Ge F, Huang W, Chen Z, Zhang C, Xiong Q, Bowler C, Yang J, Xu J, Hu H. Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum. Plant Cell 2014; 26(4): 1681-1697.

12. Xiong Q#, Zhong Q#, Zhang J, Yang M, Li C, Zheng P, Bi LJ, Ge F. Identification of Novel miR-21 Target Proteins in Multiple Myeloma Cells by Quantitative Proteomics. Journal of Proteome Research 2012; 11(4):2078-90

13. Xiong Q, Ge F. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients. Expert Review of Proteomics 2011; 8 (4):439-442.

14. Zhao Y#, Xiong Q#, Xie P. Analysis of miRNA Expression in embryonic developmental toxicology induced by MC-RR. PLoS ONE 2011,6 (7): e22676.

15. Xiong Q, Xie P, Li H, Hao L, Li G, Qiu T, Liu Y. Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney and testis) of male Wistar rats. Journal of biochemical and molecular toxicology 2010; 24 (6): 361-367.

16. Xiong Q, Xie P, Li H, Hao L, Li G, Qiu T, Liu Y. Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins. Toxicon 2009; 54 (1):1-7.

相关专著章节:

[1] Xiong Q, Chen Z, Ge F. Cyanobacteria: Omics and Manipulation Chapter 7: Proteomic Analysis of Post Translational Modifications in Cyanobacteria 2017 by Caister Academic Press, Pages: 145-160.

相关专利:

[1] CN207958198U 熊倩, 等. 蛋白质分离提取装置

主持相关项目课题:

[1] microRNA-21在微囊藻毒素诱导的心血管损伤中的分子机制研究,国家自然科学基金(青年基金项目),2013.01-2015.12

[2] 藻毒素诱导心血管损伤的分子机制研究,淡水生态与生物技术国 家重点实验室开放基金,2015.01-2015.12

[3] 蓝藻的定量乙酰化蛋白质组学研究,中国科学院知识创新工程青年人才领域前沿项目, 2014.01-2015.12

[4] 蛋白质组学方法研究狐尾藻在长江流域分布格局与演化历史,中国科学院B类先导科技专项培育项目子课题任务,2017.7-2018.6

[5] 蛋白质组学方法研究狐尾藻在长江流域分布格局与演化历史,中国科学院B类先导科技专项子课题任务,2018.7-2023.7

 
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