导师队伍
| 职 称： | 研究员 |
|---|---|
| 学 历： | 博士研究生 |
| 联系方式： | 86-027-68780053 |
| 电子邮件： | liaihua#ihb.ac.cn(请改#为@) |
| 办 公 室： | 1号实验楼512 |
| 个人网页： |
简历介绍：
博士，研究员，博士生导师。1985年，江西农业大学兽医系毕业，获学士学位；1988年，江苏农业大学兽医系毕业，获硕士学位；1998年，中国科学院水生生物研究所，获博士学位；1999-2000年，丹麦皇家农业与兽医大学(KVL)访问学者；2002-2004年，韩国国立健康研究院(Korean NIH)，博士后。现任中国兽药典委员会委员、农业部兽药评审委员会委员、中国水产学会鱼病学专业委员会委员。
长期从事细菌性鱼病及其防治技术的研究工作。在国内或国际上首次报道了多种鱼类细菌性疾病，包括：虹鳟鱼的魏斯氏菌（Weissellasp）病，这是国际上该细菌作为病原菌的首次报道，并得到了国际同行后续的证实；报道鲟鱼的分枝杆菌病，包括发现了2种新的鱼类致病性分枝杆菌- Mycobacterium porcinum和Mycobacterium arpuense；鲟鱼的的停乳链球菌（Streptococcus dysgalactiae）病；黄颡鱼的鲶爱德华氏菌（Edwardsiellaictaluri）病；乌鳢的舒伯特气单胞菌（Aeromonas schubertii）病，圆口铜鱼的杀鲑气单胞菌（Aeromonas salmonicida）病。
此外，在渔药毒理学、渔药药效学的临床评价、水产动物药代动力学、鱼类病原菌耐药性及耐药机理、环境胁迫对鱼类非特异性免疫功能的影响等领域在国内做出了开创性的研究
先后主持或参与承担了973项目、国家自然科学重点基金，国家自然科学基金面上项目，国家科技攻关项目，国家支撑计划项目，中国科学院知识创新工程项目，教育部留学回国人员择优基金，省院合作项目、省自然科学基金。发表论文74篇，其中SCI论文40多篇，
获发明专利2项，正在申请的发明专利1项，参编或主编著作11部。此外，多次赴国外参加相关的学术交流活动。
研究方向：
鱼类细菌性疾病病原生物学、致病机理及防治技术。
代表论著：
1. Tongtong Li, Meng Long, Cheng Ji, Zhixin Shen, Fran？ois-Jo？lGatesoupe, Xujie Zhang, Qianqian Zhang, Lanli Zhang, Yuanli Zhao, Xinhua Liu, Aihua Li. Alterations of the gut microbiome of largemouth bronze gudgeon (Coreiusguichenoti) suffering from furunculosis. Scientific Reports, 2016,6:30606. doi: 10.1038/srep30606。（通讯作者）
2. Meng Long, Tue K. Nielsen, Jorgen J. Leisner, Lars H. Hansen, Zhi X. Shen,Qian Q. Zhang, Aihua Li. Aeromonas salmonicida subsp. salmonicida strains isolated from Chinese freshwater fish contain a novel genomic island and possible regional-specific mobile genetic elements profiles. FEMS Microbiology Letters 2016, 363 (17): fnw190.Doi: 10.1093/femsle/fnw190 （通讯作者）
3. Ji Y, Li J, Qin Z, Li A, Gu Z, Liu X, Lin L, Zhou Y
*. Contribution of nuclease to the pathogenesis of Aeromonas hydrophila. Virulence, 2015,6(5):515-522, SCI IF: 4.2.
4. Wu N, Zhang XY, Huang B, Zhang N, Zhang XJ, Guo X, Chen XL, Zhang Y, Wu H, Li S, Li AH, Zhang YA*. Investigating the potential immune role of fish NCAMs: Molecular cloning and expression analysis in mandarin fish. Fish and Shellfish Immunology, 2015, 46(2): 765-777.
5. Xiaojuan Hu, Xiangping Hu, Baoqing Hu, Chungen Wen , YanhaiXie, Dan Wu, Zhiying Tao, Aihua Li, Qian Gao. Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristariaplicata. Fish & Shellfish Immunology, 2014, 40: 446-454.
6. Meng Long, Juan Zhao, Tongtong Li, Carolina Tafalla, Qianqian Zhang, Xiehao Wang, Xiaoning Gong, Zhixin Shen, Aihua Li. Transcriptomic and proteomic analysis of splenic immune mechanisms of rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida subsp. salmonicida. Journal of Proteomics, 2015,122:41–54（通讯作者）
7. Xujie Zhang, Wuming Yang, Han Wu, Aihua Li. Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicaemia outbreaks in pond cultured cyprinid fish in an epidemic area, central China. Aquaculture, 2014, 32: 1-6.（通讯作者）。
8. Tongtong Li, MengLong ,Fran？ois-Jo？lGatesoupe,Qianqian Zhang, Aihua Li&Xiaoning Gong. Comparative analysis of the intestinal bacterial communities in different species of carp by pyrosequencing. Microbial Ecology, August 2014 DOI 10.1007/s00248-014-0480-8（通讯作者）
9.Zhang Defeng, Zhang Qianqian&Li Aihua. Development of a multiplex PCR assay for rapid and simultaneous detection of four genera of fish pathogenic bacteria. Letters in Applied Microbiology 2014，59: 471–478. doi:10.1111/lam.12303 （通讯作者）。
10.Defeng Zhang,Aihua Li, YujuanGuo, Qianqian Zhang, Xuenian Chen, Xiaoning Gong.Molecular characterization of Streptococcus agalactiaein diseased farmed tilapia in China. Aquaculture, 2013,412–413:64–69. （通讯作者）
11. Li Juan Zhao, Jin Fang Lu, P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie.Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiellaictaluri. Veterinary Microbiology, 2013, 166 :233–241.
12. Bao-Qing Hu , Yi Liu , Chun-Gen Wen , Ai-Hua Li , Xiang-Ping Hu, Dan Wu, Xiao-Juan Hu, Zhi-Ying Tao.Cloning and expression of selenoprotein W from pearl musselsCristariaplicata. Comparative Biochemistry and Physiology Part B，2014，167：8-15（通讯作者）.
13. Xu-Jie Zhang, Wu-Ming Yang, De-Feng Zhang, Tong-Tong Li, Xiao-Ning Gong &Ai-Hua Li. Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassiuscarassius)? Aquaculture Research, 2013, 1–14.（通讯作者）
14.Liu Jinyu&Li Aihua. First case of Aeromonas schubertii infection in the freshwater cultured snakehead fish, Ophiocephalusargus(Cantor), in China. Journal of Fish Diseases 2012, 35, 335–342.（通讯作者）
15.Cheng Ji, De Feng Zhang, Ai Hua Li, Xiao Ning Gong. Effect of berberinehydrochloride on grass carp Ctenopharyngodonidella serum bactericidal activity against Edwardsiellaictaluri. Fish & Shellfish Immunology, 2012,33 (1):143-145. （通讯作者）
16. Ji Cheng, Li Aihua, Xie Jun, Zhang Defeng& Liu Jinyu. Bactericidal activity of grass carp CtenopharyngodonidellaC9-deficient serum against Aeromonas hydrophila. Journal of Fish Biology (2011) 79, 2083–2086. （通讯作者）
17. JinYu Liu, Ai Hua Li, Dong Ren Zhou, Zhou RuiWen&XuePingYe. Isolation and characterization of Edwardsiellaictaluri strains as pathogens from diseased yellow catfish Pelteobagrusfulvidraco(Richardson) cultured in China. Aquaculture Research, 2010,41:1835-1844. （通讯作者）
18. Defeng Zhang, Aihua Li, Jun Xie & Cheng Ji. In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria. Aquaculture Research, 2010,41:1095-1100. （通讯作者）
19. Jinyu Liu, Wuming Yang, Cheng Ji, AihuaLi.. First description of a novel lactic acid bacterium Weissella sp. isolated from diseased rainbow trout Oncorhynchus mykiss (Walbaum) in China. Veterinary Microbiology , 2009,136: 314–320.（通讯作者）
20. Wuming Yang, Aihua Li. Isolation and characterization of Streptococcus dysgalactiae from diseased Acipenserschrenckii. Aquaculture, 2009.294:14-17. （通讯作者）
21. 张倩倩，刘天强，李彤彤，徐静，龙梦，王谢昊，李爱华*。玉屏风散对鱼类非特异性免疫和免疫相关基因表达的影响。水生生物学报，2015，39（6）：1076~1084。